Isolated Recurrence of Granulocytic Sarcoma -Two Case Reports-

Abstract

Two patients presented with rare isolated recurrence of granulocytic sarcoma. A 29-year-old male presented with an extra-and intracranial mass 10 years after bone marrow transplantation for chronic myeloid leukemia. A 34-year-old female presented with an intracranial mass 3 years after complete remission of acute myeloid leukemia-M2a. Both patients underwent surgical resection. The first patient received adequate postoperative radiotherapy and chemotherapy, and achieved complete remission without evidence of diseases during the 6-month follow up. The second patient only received whole brain radiotherapy, failed to respond, and died of systemic leukemia later. These two cases demonstrate that neurosurgeons should pay attention to the occurrence of isolated recurrent granulocytic sarcoma, especially in patients with a history of hematologic neoplasm. Immediate pathological and cytogenetic diagnoses are essential.

Isolated Recurrence of Intracranial and Temporal Bone Myeloid Sarcoma -Case Report-

“…9,12) Unusual manifestations of extraand intracranial locations of MS have been reported. 9,17,18) In our case, we speculate that the marrow space of the petrous bone was first involved by leukemic cells, then tumor mass developed and extended to the mastoid cavity and intracranial space. MS has been described in association with various chromosomal abnormalities such as t(8;21)(q22;22) translocations, mixed lineage leukemia rearrangements, trisomy 8, and inversion 16.…”

Successful Treatment of Duodenal Myeloid Sarcoma with Allogeneic Bone Marrow Transplantation and Additional Radiotherapy

“…In some cases involving a large mass or multiple lesions, long-term survival was achieved by performing the transplant with the patient in a non-CR state; however, these lesions make accurate evaluation of the extent of any residual disease remaining after chemotherapy difficult (7)(8)(9). On the other hand, some case reports demonstrated that MS relapsed after allo-HCT for leukemia (12,13). Xu et al reported the case of a patient who presented with extra-and intracranial MS after undergoing a transplant for chronic myelogenous leukemia.…”

“…Xu et al reported the case of a patient who presented with extra-and intracranial MS after undergoing a transplant for chronic myelogenous leukemia. The patient was successfully treated with surgical resection and postoperative radiotherapy and chemotherapy (12). Kai et al reported the case of a patient with acute promyelocytic leukemia who suffered serial extramedullary MS relapses after undergoing allogeneic peripheral blood stem cell transplantation (allo-PBSCT).…”