Isolated Pyridoxine Deficiency Presenting as Peripheral Neuropathy Post-chemotherapy

Abstract

Pyridoxine deficiency is a rare but identifiable cause of sideroblastic anemia, depression, and peripheral neuropathy. Platinum-based chemotherapeutic drugs display structural similarity to pyridoxine, which interferes with the absorption and hence the efficacy of the drug. If left untreated, it can lead to irreversible axonal loss and permanent deficits, leading to falls. Our case is a highly unusual scenario of isolated pyridoxine deficiency presenting as peripheral neuropathy and depression as a delayed side effect of chemotherapeutic drugs.