“…The coexistence of different molecular defects may change the clinical and laboratory manifestation of MPN. In 2016 Fozza et al reported a case of JAK2 V617F and BCR‐ABL1 positive CML, manifesting isolated polyglobulia many months before the appearance of the classical hematological pattern. It was also observed in case no.…”
In our opinion, a detailed evaluation and appropriate interpretation of clinical and laboratory data in such a category of patients seem to be extremely important, especially when a decision about the TKI change due to therapy failure is considered.
“…The coexistence of different molecular defects may change the clinical and laboratory manifestation of MPN. In 2016 Fozza et al reported a case of JAK2 V617F and BCR‐ABL1 positive CML, manifesting isolated polyglobulia many months before the appearance of the classical hematological pattern. It was also observed in case no.…”
In our opinion, a detailed evaluation and appropriate interpretation of clinical and laboratory data in such a category of patients seem to be extremely important, especially when a decision about the TKI change due to therapy failure is considered.
“…However, extremely rare confounding scenarios should always be considered and include the co-existence of CML and PV and singular cases of CML presenting with polycythemia [4,5]. While JAK2 mutation analysis for PV remains high in the diagnostic algorithm for investigation of polycythemia and erythrocytosis [2], more common reasons should be excluded before subsequent investigation of rare underlying causes.…”
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