Isolated Optic Disc Granuloma as a Presenting Sign of Sarcoidosis

Oyeniran, Enny; Katz, David M.; Kodati, Shilpa

doi:10.1080/09273948.2022.2127783

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Although less common than anterior involvement, it is more threatening to the patient's vision [61]. Authentic choroidal granulomas in peripheral retina or around the optic nerve have been described but multifocal choroiditis (Figure 2) is much more common [50,62,63]. Both lesions can evolve into atrophic scars of the pigmentary epithelium.…”

Section: Posterior Uveitismentioning

confidence: 99%

Sarcoidosis-Related Uveitis: A Review

Giorgiutti

Jacquot

Jammal

et al. 2023

JCM

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Sarcoidosis is an inflammatory disease that involves the eyes in 10–55% of cases, sometimes without systemic involvement. All eye structures can be affected, but uveitis is the most common ocular manifestation and causes vision loss. The typical ophthalmological appearance of these uveitis is granulomatous (in cases with anterior involvement), which are usually bilateral and with synechiae. Posterior involvement includes vitritis, vasculitis and choroidal lesions. Tuberculosis is a classic differential diagnosis to be wary of, especially in people who have spent time in endemic areas. The diagnosis is based on histology with the presence of non-caseating epithelioid granulomas. However, due to the technical difficulty and yield of biopsies, the diagnosis of ocular sarcoidosis is often based on clinico-radiological features. The international criteria for the diagnosis of ocular sarcoidosis have recently been revised. Corticosteroids remain the first-line treatment for sarcoidosis, but up to 30% of patients require high doses, justifying the use of corticosteroid-sparing treatments. In these cases, immunosuppressive treatments such as methotrexate may be introduced. More recent biotherapies such as anti-TNF are also very effective (as they are in other non-infectious uveitis etiologies).

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Section: Posterior Uveitismentioning

confidence: 99%