Isolated omental metastasis of renal cell carcinoma after extraperitoneal open partial nephrectomy: A case report

Acar, Ömer; Mut, Tuna; Sağlıcan, Yeşim; Sag, Alan A.; Falay, Okan; Selçukbiricik, Fatih; Tabak, Levent; Esen, Tarık

doi:10.1016/j.ijscr.2016.02.008

Cited by 9 publications

(7 citation statements)

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“…These can be classified into three subcategories, i.e. first as presentation with disseminated peritoneal disease, second as recurrence after initial nephrectomy [ 20 ] and third, most common nowadays, as port site and omental mets after the laparoscopic excision of renal masses. Stavropoulos et al reported a case who presented with peritoneal metastasis and noted that the incidence of peritoneal metastasis in renal cell carcinoma is about 1% at autopsy [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Pandey

Mahendran

Shukla³

2018

World J Surg Onc

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BackgroundSunitinib is a multiple receptor tyrosine kinase inhibitor (TKI) used for the treatment of renal cell carcinoma (RCC). It increases the median survival considerably with minimum side effects. Alopecia is one of the rare side effects. Metastasis to the ovary is also rare. We report a case of RCC metastasizing to the ovary developing alopecia early on starting sunitinib.Case presentationA 22-year-old hypothyroid girl underwent right radical nephrectomy for T2N0 RCC. Histopathology was clear cell carcinoma. Six months later, she presented with right iliac fossa pain, imaging revealed metastasis to the ileocolic junction and the ovary, an exploratory laparotomy was carried out and, after debulking, the patient was started on sunitinib. Four weeks after the start of the treatment, she developed alopecia. She was continued with sunitinib therapy till progression.ConclusionsThe present case shows a rare metastasis to the ovary and early onset of rare adverse event of alopecia on starting sunitinib therapy. In the presence of confounding factors like hypothyroidism and dandruff, establishing this as an adverse reaction of sunitinib is difficult. This case had a unique metastatic spread with involvement of the bowel, ovary and peritoneal carcinomatosis. Use of adjuvant TKI's after resection of primary tumour in nonmetastatic setting may reduce metastatic rates and increase progression-free survival.

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Section: Discussionmentioning

confidence: 99%

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Pandey

Mahendran

Shukla³

2018

World J Surg Onc

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“…The patient was totally asymptomatic. While metastasis of RCC in the liver and mediastinum is frequently observed, omental metastasis is very rare [ 16 ]. Metastasis to the thyroid is relatively rare, despite its rich blood supply.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports

Bruckschen¹,

Gerharz²,

Sagir³

2021

J Med Case Reports

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Introduction Renal cell carcinoma is the third most common malignant tumor in the urogenital tract. An estimated 25% of renal cell carcinomas are in stage IV when diagnosed. The 5-year-survival with stage IV is about 20%. Late metastases are found after an extended disease-free interval up to 20 years after primary nephrectomy. Case presentation Here, we present two cases with late-onset metastasis of renal cell carcinoma with different clinical presentations. The first patient, an 88-year-old Caucasian man, presented with bleeding of the upper gastrointestinal tract. Biopsies taken from the duodenal bulb showed a tumor compatible with a solitary metastasis from renal cell carcinoma 22 years ago. The second patient, a 79-year-old Caucasian man, consulted our gastroenterological department with results of an outpatient computed tomography scan with multiple suspected tumor areas in the liver, omentum, thyroid, and mediastinum. A computed tomography-guided liver biopsy was performed that showed a clear-cell tumor consistent with a metastasis of the renal cell carcinoma 17 years ago. Conclusion Both cases show that patients with a history of renal cell carcinoma should be followed up for a longer time than patients with other malignant tumors.

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“…Few recent studies have evaluated the role of FDG-PET/CT in response to tyrosine kinase inhibitors in metastatic RCC. [19]…”

Section: Discussionmentioning

confidence: 99%

Krukenburg tumors arising from rare primary sites: Role of ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography in management and outcome

et al. 2019

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Krukenberg tumors described by Friedrich Ernst Krukenberg are still fascinating for their mysterious origin. It is known to be a rare entity and commonly originates from adenocarcinoma of stomach. We present three interestingly rare cases of this entity, revealed by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (F-18 FDG-PET/CT) scan and discuss how F-18 FDG-PET/CT can prognosticate, alter the course of treatment in such patients. Ovarian metastatic deposits were detected in patients with renal cell, duodenal, and gall bladder carcinoma. Three visits were possible in patient with duodenal cancer (favorable response to therapy), two visits in renal cell cancer (progressive disease pattern) and only single visit for gall bladder cancer. Potentials of F-18 FDG-PET/CT scan for Krukenberg disease is still in exploratory phase, but it's applications in diagnosis, disease monitoring, therapeutic response monitoring, and prognosticating are unparalleled with other imaging modalities.

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Isolated omental metastasis of renal cell carcinoma after extraperitoneal open partial nephrectomy: A case report

Cited by 9 publications

References 10 publications

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports

Krukenburg tumors arising from rare primary sites: Role of ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography in management and outcome

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Isolated omental metastasis of renal cell carcinoma after extraperitoneal open partial nephrectomy: A case report

Cited by 9 publications

References 10 publications

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female

Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports

Krukenburg tumors arising from rare primary sites: Role of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in management and outcome

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Krukenburg tumors arising from rare primary sites: Role of ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography in management and outcome