Isolated Neurosarcoidosis Mimicking Demyelination and Metastases

Abstract

Involvement of the central nervous system (CNS) is commonly seen in patients with systemic sarcoidosis; however, an isolated case of neurosarcoidosis is a substantially infrequent scenario. Neurosarcoidosis may present with numerous nonspecific clinical manifestations and radiological features, which makes it difficult to diagnose. Correct interpretation of magnetic resonance imaging (MRI) findings incorporating sarcoidosis as a possible diagnosis is important for timely management of the disease. We report the unusual case of a 47-year-old female with brain lesions and a sudden appearance of spinal lesions mimicking CNS demyelination and metastases. Biopsy provided a definitive diagnosis of neurosarcoidosis.