Isolated Myeloid Sarcoma of the Gastrointestinal Tract

Elezović, Ivo; Bogdanović, Andrija; Suvajdzic-Vukovic, Nada; Pavlović, Aleksandra; Jovanović, Marina; Jaković, Ljubomir; Kraguljac, Nada

doi:10.2169/internalmedicine.49.2874

Cited by 17 publications

(17 citation statements)

References 20 publications

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“…Pediatric myeloid sarcoma has a prevalence of about 0.7 in one million children and can progress to AML [16, 17]. Infiltration of the gastrointestinal tract, including the ileum, has been reported in AML [18, 19].…”

Section: Discussionmentioning

confidence: 99%

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

et al. 2016

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BackgroundNeonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are common in neonatal AML.Case presentationA female neonate born at 34 weeks gestation presented with cardiorespiratory failure, hepatosplenomegaly, pancytopenia, and coagulopathy. She required intensive care treatment including mechanical ventilation, high-dose catecholamine therapy, and multiple transfusions. Small intestinal biopsy obtained during laparotomy for meconium ileus revealed an infiltrate by an undifferentiated monoblastic, MLL-rearranged leukemia. No other manifestations of leukemia could be detected. After spontaneous clinical remission, lasting 5 months without any specific treatment, the patient presented with leukemia cutis and full-blown monoblastic leukemia. MLL-AF10-rearranged AML could be re-diagnosed and successfully treated with chemotherapy and hematopoietic stem cell transplantation.ConclusionsOur patient exhibited a unique manifestation of neonatal MLL-AF10 rearranged AML with cardiorespiratory failure and intestinal infiltration. It highlights the importance of leukemia in the differential diagnosis of neonatal distress, congenital hematological abnormalities, and skin lesions.

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Section: Discussionmentioning

confidence: 99%

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

et al. 2016

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“…CT imaging might show focal bowel wall thickening, a single mass, polyps, multiple masses obstructing the gut lumen, or exophytic lesions involving the peritoneum [12]. There have been cases of myeloid sarcoma localized to the oral cavity [13], esophagus, stomach, jejunum [14–16], gallbladder [17], bile ducts [18], pancreas [19, 20], colon [21], liver [21], or appendix [22] or may diffusely involve the GI tract [23–25] including the abdominal wall [26]. When small and large bowels are involved, it is more likely to spread to the mesentery and peritoneum.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

Parsa

Bijpuria

Ringold

et al. 2012

Case Reports in Medicine

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Myeloid Sarcoma is a rare tumor composed of myeloblasts occurring at an extramedullary site like bones, or various soft tissues. Myeloid sarcoma may involve the gastrointestinal tract very rarely either solitarily, or occurring simultaneously with acute myeloid leukemia. Its diagnosis is challenging and needs biopsy and immunohistochemical staining. We are describing a case of myeloid sarcoma which presented as a painful anal ulcer mimicking an atypical fissure. Its appearance resembled crohn's disease on sigmoidoscopy. A biopsy of the ulcer along with histochemical staining led to the diagnosis of myeloid sarcoma. Our case demonstrates the need for aggressive evaluation of any common gastrointestinal complaint with an atypical presentation.

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“…Ancak ikiden daha fazla organda tutulumun görülmesi sık rastlanan bir durum değildir (5). Akut miyeloid lösemiye (AML), miyelodisplastik bozukluğa ve miyelodisplastik sendroma dönüşebilmektedir (6). Bazen de lösemi bulguları olmaksızın solid bir tümör şeklinde ortaya çıkabilirler.…”

Section: Introductionunclassified

A rare cause of mechanical obstruction: Intestinal myeloid sarcoma

Yoldaş¹,

Erol²,

Demir³

et al. 2014

UCD

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Myeloid sarcoma is a rare aggressive tumour that originates from immature extramedullary myeloid cells. It can be seen as a relapse in patients with acute myeloid leukaemia. Sometimes it can be seen in the form of a solid tumour without any evidence of leukaemia. A case of a 44-year-old male patient who was admitted with symptoms and signs of mechanical intestinal bowel obstruction was operated on. The operation findings showed small bowel obstruction due to a mass. The mass was then resected with end-to-end intestinal anastomosis. The resected mass pathology results were consistent with myeloid sarcoma. The post-operative period was uneventful and adjuvant therapy was applied. In this case report we aimed to evaluate the clinical signs and treatment modalities of small intestinal myeloid sarcoma.

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Isolated Myeloid Sarcoma of the Gastrointestinal Tract

Abstract: Myeloid sarcoma (MS) is

Cited by 17 publications

References 20 publications

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

A rare cause of mechanical obstruction: Intestinal myeloid sarcoma

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