Isolated Multiple Bilateral Thyroid Metastases from Prostatic Adenocarcinoma: Case Report and Literature Review

Abstract

Solitary metastasis from prostate adenocarcinoma to thyroid gland is very rare and usually associated with other distal metastasis. This report describes for the first time isolated multiple bilateral thyroid metastasis from prostatic adenocarcinoma. A 67-year-old man who is known as a case of prostatic adenocarcinoma was admitted to a hospital as a case of a multinodular goiter on the basis of clinical and CT scan findings. Total thyroidectomy was performed and histopathology result showed adenomatous goiter containing bilateral metastatic prostatic adenocarcinoma. This is the first report of isolated multiple bilateral thyroid gland metastasis from prostatic adenocarcinoma without other distal metastasis. Such lesions are very rare and can be misdiagnosed, so high index of suspicion for thyroid metastasis should be always maintained in all oncology patients with isolated thyroid mass because early resection and thyroidectomy will change the prognosis for patient.

PSMA expression in multinodular thyroid neoplasm on simultaneous Ga-68-PSMA PET/MRI

“…[101112] Although rare, metastatic spread to the thyroid gland from primary PCa has been reported in the past. [1314] In this patient, metastases to the thyroid was a distinct possibility in view of widespread metastatic disease not observed in this case. So, in a case of PSMA avid thyroid lesion, it is important to differentiate metastases with primary thyroid neoplasm with biopsy before initiating further treatment.…”

Secondary or Second Primary Malignancy in the Thyroid? Metastatic Tumors Suggested Clinically: A Differential Diagnostic Task

“…In the scientific literature, many cases of metastatic tumors in the thyroid have been published as case reports describing the pitfalls of individual case diagnosis supported by a literature overview, stressing the specific context of the more frequent primary malignancies or the reporting a rare malignancy metastasizing to the thyroid [11,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]. Meta-analyses are available for the most frequent primary malignancies [32,33].…”

Thyroid Incidentaloma on 68Ga-PSMA-11 PET/CT Leading to Detection of Thyroid Metastasis in Metastatic Prostate Carcinoma

“…9 A very few case reports have been found in the literature with thyroid metastasis from prostatic adenocarcinoma. 10 Focal uptake on 68 Ga-PSMA-11 PET/CT in an unusual site should be interpreted cautiously and should preferably be correlated with FNAC/ biopsy for appropriate diagnosis.…”

“…Rarely, metastatic spread of prostatic adenocarcinoma occurred to the head and neck region particularly in relation to thyroid gland 9 . A very few case reports have been found in the literature with thyroid metastasis from prostatic adenocarcinoma 10 . Focal uptake on 68 Ga-PSMA-11 PET/CT in an unusual site should be interpreted cautiously and should preferably be correlated with FNAC/biopsy for appropriate diagnosis.…”