Isolated lingual nodular amyloidosis

López, José Darío Sánchez; Ruiz, Juan Andrés Rodríguez; Rico, Angel Martínez-Sahuquillo

doi:10.1016/j.medcle.2019.06.027

Cited by 1 publication

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“…The term amyloidoma is defined as a localized tumoral deposit of AL or AA amyloid in the absence of systemic amyloidosis [3]. Amyloidomas have been described in widely varied anatomic sites besides the skin, including the genitourinary, respiratory, and gastrointestinal tracts, the breast, eye, bone, and tongue [4,5]. Case reports with amyloidosis affecting the nail unit are sparse and usually limited to nail changes in the context of systemic amyloidosis [6][7][8].…”

Section: Introduction/literature Reviewmentioning

confidence: 99%

Nail Amyloidoma: Two Case Reports of a New Entity

Bonito¹,

Kolivras²,

Saß³

et al. 2023

Skin Appendage Disord

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Introduction: Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity. Case Presentation: Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up. Conclusion: These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis.

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