Isolated left ventricular hypoplasia - A singularity

Choh, Naseer A.; Amreen, Saika; Mir, Amber Bashir; Malik, Aadil Hussain; Hameed, Mudasir; Shaheen, Feroze; Gojwari, Tariq

doi:10.4103/apc.apc_88_19

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Isolated LV apical hypoplasia has a variable phenotype with presentations ranging from asymptomatic to congestive cardiac failure, as seen in the present patient. [ 5 – 7 ] A case series of five young patients with the condition describes cyanosis in two of the patients, although these patients had associated persistent ductus arteriosus and severe pulmonary hypertension. [ 8 ] Indeed, there has been a case report of death on first presentation in a 19-year-old who died of ventricular tachyarrhythmias and multi-organ dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Isolated Left Ventricular Apical Hypoplasia

Dattani

Prasad

2021

Card Fail Rev

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Section: Discussionmentioning

confidence: 99%

Isolated Left Ventricular Apical Hypoplasia

Dattani

Prasad

2021

Card Fail Rev

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Multimodality imaging for the diagnosis of left ventricular apical hypoplasia: A case presentation and review of the literatures

Liao,

Jin,

Miao

et al. 2024

Echocardiography

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Left ventricular apical hypoplasia is a rare malformation recently described congenital abnormality characterized by: (1) truncation of the left ventricle, with the septum projecting toward the right ventricle; (2) abnormal papillary muscle originating from the flattened left ventricular apex; (3) a narrow right ventricle encompassing the periapical area of the left ventricle; (4) fatty infiltration of the apex of the left ventricle. We reported a case of LVAH and reviewed the patient's clinical presentation. And its morphologic characteristics were revealed by multimodality imaging, including echocardiography and cardiac magnetic resonance imaging. Additionally, we reviewed 41 cases from 32 reports to summarize the pathogenesis and analyzed the imaging manifestations of LVAH in this study, aiming to provide new ideas for the diagnosis and clinical management of LVAH patients.

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Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

Bassareo¹,

Duignan²,

James³

et al. 2023

World J Clin Cases

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Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and the leading contributor to cancer-related deaths. The progression and metastasis of HCC are closely associated with altered mitochondrial metabolism, including mitochondrial stress response. Mitokines, soluble proteins produced and secreted in response to mitochondrial stress, play an essential immunomodulatory role. Immunotherapy has emerged as a crucial treatment option for HCC. However, a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor microenvironment. Therefore, exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of immunotherapy. This study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver function. In addition, a systematic review of mitokines-mediated immunomodulation in HCC is presented. Finally, the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and summarized. Recent progress in mitokine research represents a new prospect for mitochondrial therapy. Considering the potential of mitokines to regulate immune function, investigating them as a relevant molecular target holds great promise for the diagnosis and treatment of HCC.

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Isolated left ventricular hypoplasia - A singularity

Cited by 3 publications

References 6 publications

Isolated Left Ventricular Apical Hypoplasia

Isolated Left Ventricular Apical Hypoplasia

Multimodality imaging for the diagnosis of left ventricular apical hypoplasia: A case presentation and review of the literatures

Isolated left ventricular apical hypoplasia: Systematic review and analysis of the 37 cases reported so far

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