Isolated Lactase Deficiency in Humans

An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture.

“…Disaccharidase activities in biopsy specimens were measured for all patients and controls participating in the study. Initial disaccharidase activities in specimens obtained from normal control patients were comparable to those reported by others (17)(18)(19). In general disaccharidase adtivity increased during organ culture although not to the same degree as alkaline phosphatase activities.…”

An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture.

“…Disaccharidase activities in biopsy specimens were measured for all patients and controls participating in the study. Initial disaccharidase activities in specimens obtained from normal control patients were comparable to those reported by others (17)(18)(19). In general disaccharidase adtivity increased during organ culture although not to the same degree as alkaline phosphatase activities.…”

Lactase Deficiency in Patients with Intestinal Schistosomiasis

“…The abdominal distention found in the patient groups may be due initially to liquid in the small intestine rather than due to gas in the colon as described by Welsh [22]. The abdominal distention was associated with meteorism, borborygmi, and abdominal colic.…”

The effect of continued feeding of physiological amounts of lactose on the level of intestinal lactase and other disaccharidase enzyme activities in the rat

“…It appears, therefore, that in the normal situation, as seen in the majority of human population and other placental mammals, a recessive gene controls the loss of lactase activity. These findings were also substantiated by family studies in several other communities (Flatz & Saengudom, 1969;Gudmand-Hoyer & Jarnum, 1969;Welsh, 1970;Gilat, Benaroya, Gelman-Malachi & Adam, 1973). Persistence of high intestinal lactase activity into adult life, as far as we know, is only observed in man and is believed to have arisen as a result of a genetic mutation that had taken place some 10000 years ago in some dairying communities and has persisted because of nutritional advantage and the dominant nature of the mutant gene (Simoons, 1970;Flatz & Rotthauwe, 1973).…”

An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture.

“…Disaccharidase activities in biopsy specimens were measured for all patients and controls participating in the study. Initial disaccharidase activities in specimens obtained from normal control patients were comparable to those reported by others (17)(18)(19). In general disaccharidase adtivity increased during organ culture although not to the same degree as alkaline phosphatase activities.…”

Lactase Deficiency in Patients with Intestinal Schistosomiasis

“…The abdominal distention found in the patient groups may be due initially to liquid in the small intestine rather than due to gas in the colon as described by Welsh [22]. The abdominal distention was associated with meteorism, borborygmi, and abdominal colic.…”

The effect of continued feeding of physiological amounts of lactose on the level of intestinal lactase and other disaccharidase enzyme activities in the rat

“…It appears, therefore, that in the normal situation, as seen in the majority of human population and other placental mammals, a recessive gene controls the loss of lactase activity. These findings were also substantiated by family studies in several other communities (Flatz & Saengudom, 1969;Gudmand-Hoyer & Jarnum, 1969;Welsh, 1970;Gilat, Benaroya, Gelman-Malachi & Adam, 1973). Persistence of high intestinal lactase activity into adult life, as far as we know, is only observed in man and is believed to have arisen as a result of a genetic mutation that had taken place some 10000 years ago in some dairying communities and has persisted because of nutritional advantage and the dominant nature of the mutant gene (Simoons, 1970;Flatz & Rotthauwe, 1973).…”

An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture.

“…Disaccharidase activities in biopsy specimens were measured for all patients and controls participating in the study. Initial disaccharidase activities in specimens obtained from normal control patients were comparable to those reported by others (17)(18)(19). In general disaccharidase adtivity increased during organ culture although not to the same degree as alkaline phosphatase activities.…”

Lactase Deficiency in Patients with Intestinal Schistosomiasis

“…The abdominal distention found in the patient groups may be due initially to liquid in the small intestine rather than due to gas in the colon as described by Welsh [22]. The abdominal distention was associated with meteorism, borborygmi, and abdominal colic.…”

The effect of continued feeding of physiological amounts of lactose on the level of intestinal lactase and other disaccharidase enzyme activities in the rat

“…It appears, therefore, that in the normal situation, as seen in the majority of human population and other placental mammals, a recessive gene controls the loss of lactase activity. These findings were also substantiated by family studies in several other communities (Flatz & Saengudom, 1969;Gudmand-Hoyer & Jarnum, 1969;Welsh, 1970;Gilat, Benaroya, Gelman-Malachi & Adam, 1973). Persistence of high intestinal lactase activity into adult life, as far as we know, is only observed in man and is believed to have arisen as a result of a genetic mutation that had taken place some 10000 years ago in some dairying communities and has persisted because of nutritional advantage and the dominant nature of the mutant gene (Simoons, 1970;Flatz & Rotthauwe, 1973).…”