Isolated intraosseous extra-gnathic orbital myxoma: a clinicopathologic case report

Manjandavida, Fairooz P; Chahar, Shaifali; Dave, Brijal

doi:10.1080/01676830.2018.1538381

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…1 , 2 , 3 Conjunctival myxoma, usually present in older people, was first described in 1913 by Magalif, followed by limited number of case reports. Other than conjunctiva, ocular myxoma could occur in the optic nerve, orbit, eyelid, and the cornea, 4 , 5 , 6 , 7 or develop with systemic diseases such as Zollinger-Ellison syndrome and Carney complex. In literature review, patient with Zollinger-Ellison syndrome could present with pancreatic gastrinoma, inter-atrial septal thickening, and conjunctival myxoma at the same time.…”

Section: Introductionmentioning

confidence: 99%

Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review

Hung

Yeh

2020

American Journal of Ophthalmology Case Reports

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Purpose To describe a case with a growing erythematous conjunctival mass in the left eye, diagnosed as conjunctival myxoma. Observations A 31-year-old lady had corrected visual acuity of 6/7.5 and normal intraocular pressure in both eyes. Congested left bulbar conjunctiva with one slightly elevated nodule at nasal area was noted for one year. Excisional biopsy was performed after failed treatment with topical eye drops. Pathology showed conjunctival myxoma with spindle- and stellate-shaped cells, which was a rare ocular surface neoplasia. There was no combined systemic disease found. Conclusions and importance We described the clinical and pathological features of conjunctival myxoma. Systemic evaluation should be considered before and after surgical excision.

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Section: Introductionmentioning

confidence: 99%

Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review

Hung

Yeh

2020

American Journal of Ophthalmology Case Reports

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“…To the best of our knowledge, there have only been 29 previously reported cases of myxoma of the orbit. [2,[5][6][7][8]10,13,[15][16][17][18][19]21,[23][24][25][27][28][29]31] Typically slow-growing, painless masses, these tumors may become quite large before detection, typically presenting with Radiographic characteristics of myxoma include [1,4,7] well-circumscribed lesions, soft-tissue density, bubbly, trabeculated appearance, and bony destruction with cortical thinning and/or dehiscence [ Figure 1a]. Imaging is most beneficial for initial evaluation and preoperative planning, rather than diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Orbital myxoma: A case report

Weisbrod

Smith

Camarata

et al. 2020

Surgical Neurology International

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Background: Myxomas are rare, locally infiltrative, benign neoplasms of mesenchymal origin. Although benign, these tumors are locally aggressive with a high rate of recurrence following conservative resection. Their relative infrequency, variable location, and insidious growth present a diagnostic challenge to clinicians. Cases of myxomas have been described throughout the body, but intraosseous myxomas of the orbit are exceedingly rare. Case Description: We report a case of a 53-year-old male with a history of chronic sinusitis and symptoms of hyposmia and bifrontal headaches refractory medical management who presented for neurosurgical evaluation after radiographic findings of an orbital lesion. Physical examination was unremarkable with intact extraocular movements. Prior radiographic workup demonstrated a 2.4 × 2.7 × 2.2 cm expansile lesion involving the bony left superior and lateral orbit. A prior open biopsy was performed which demonstrated a low-grade spindle cell neoplasm consistent with intraosseous myxoma. Definitive resection was recommended through the left orbitozygomatic craniotomy. The patient tolerated the procedure well without complications. Gross total resection was achieved. Reconstruction of the orbital roof and lateral orbital wall was performed with a frontal bone autograft and titanium plating. Postoperative course was uneventful, and the patient was discharged home postoperative day 2. At 1-month follow-up visit, the patient remained neurologically intact. Surveillance imaging at 6 months and 1 year remained stable without signs of recurrence. Conclusion: Intraosseous orbital myxomas are exceedingly rare entities. Although they are considered benign neoplasms, myxomas demonstrate high recurrence rates. The authors report a unique case of an orbital myxoma that was successfully treated through an orbitozygomatic approach achieving gross total resection.

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“…5 Intraosseous orbital myxomas have also been reported. 7,13 Clival lesions are rare, representing only 0.1%-0.2% of intracranial tumors, and the vast majority of these are chordomas. 1 A literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using the PubMed search engine in March 2022.…”

Section: Discussionmentioning

confidence: 99%

Clival intraosseous myxoma treated with an endoscopic endonasal approach: illustrative case

Porwal¹,

Aaronson

Razzak³

et al. 2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND Solitary lesions of the clivus, especially nonchordomatous ones, are exceptionally rare pathologies representing only 0.1%–0.2% of intracranial tumors that may present diagnostic and therapeutic challenges. Intraosseous myxomas are benign tumors arising from mesenchymal cells with an unknown pathophysiology. OBSERVATIONS In this article, a 15-year-old male with clival intraosseous myxoma who was treated via an endoscopic endonasal surgical approach is presented. The patient became symptomatic after a baseball struck his head, leading to throbbing headaches and visual difficulties for tracking objects. Examination noted diplopia, cranial nerve VI palsy, and ptosis. After imaging revealed a tumor extending to the left cavernous sinus with bulging of the dorsal clivus against the basilar artery/ventral pons, resection was performed. Postoperatively, the patient noted ocular motility and alignment improvement without further complications. LESSONS Clival masses present with symptoms from compromised neurovascular structures including visual disturbances and trigeminal sensory deficits. Given the rarity of these entities, patients may postpone further treatment until workup; this patient was misdiagnosed for possible concussion until several weeks passed. A PubMed database review of cranial myxoma cases was conducted to identify solitary clival intraosseous myxoma cases. This case is one of the few in which this pathology was treated through an endoscopic endonasal operative approach without complications, demonstrating its safety and effectiveness.

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Isolated intraosseous extra-gnathic orbital myxoma: a clinicopathologic case report

Cited by 8 publications

References 17 publications

Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review

Clinical appearance and pathological findings of conjunctival myxoma: Case report and literature review

Orbital myxoma: A case report

Clival intraosseous myxoma treated with an endoscopic endonasal approach: illustrative case

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