Isolated intraocular histiocytosis—A rarely reported entity masquerading clinically as uveitis

Moreker, Mayur R; Dudani, Ajay I; Sharma, Tanuj R; Smruti, B K

doi:10.4103/ijo.ijo_565_20

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…In one case, a diagnosis of choroidal melanoma was made, but immunohistochemical studies revealed LCH [10], and in the second eye, the iris portion of an iridociliochoroidal mass was found to be LCH after fine-needle aspiration [7]. Some reported vitreous biopsy for diagnosis of intraocular LCH [15], whereas others made the diagnosis based on a systemic history of LCH [11,16,17], as we did for our patient.…”

Section: Discussionmentioning

confidence: 59%

Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy

Ghassemi,

Riazi-Esfahani,

Ebrahimiadib

et al. 2023

Case Reports in Ophthalmological Medicine

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Background. This study is aimed at exploring a case of choroidal Langerhans cell histiocytosis (LCH) successfully treated with systemic corticosteroid and immunosuppressant. Case presentation. A 24-year-old man with known multisystem LCH developed loss of vision, ocular pain, conjunctival injection, panuveitis, and a ciliochoroidal mass. After receiving an intravenous methylprednisolone pulse, oral high-dose corticosteroids, and methotrexate, the mass resolved quickly and completely without flare-ups during 6 months of follow-up. Conclusions. Intraocular involvement of LCH is rare and can present with or without a history of multisystemic disease. The diagnosis is challenging, and the standard treatment is not established. Systemic anti-inflammatory and immunosuppressive therapy could be an effective treatment, as the LCH itself contains an essential element of inflammation and the symptoms may be mainly inflammatory.

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