Isolated Intrahepatic Biliary Dilatation in a Patient with Acquired Immune Deficiency Syndrome (AIDS)

Ks, Kumar; Nair, Soumya K; Hi, Hertan; Grover, Hemal

doi:10.1097/00004836-200101000-00018

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…A genetic predisposition has been postulated as pathogens may trigger an autoimmune-mediated reaction in patients with HLA DRw52a [8]. This may explain why the features of AIDS cholangiopathy are independent of the associated opportunistic infection [9]. …”

Section: Discussionmentioning

confidence: 99%

“…It is also better at disclosing abnormalities of the pancreas and liver [9]. However, it is less successful than ultrasound in demonstrating wall thickening and strictures of the common bile duct [7].…”

Section: Discussionmentioning

confidence: 99%

“…However, the extrahepatic manifestations of AIDS cholangiopathy are quite different from PSC (Table 2). Diverticular outpouchings, sacculations, and high-grade proximal strictures are seen in PSC while moderate ductal dilatation with irregular margins and nodules are more characteristic of AIDS cholangiopathy [9]. Isolated dilatation of intrahepatic biliary ducts in AIDS cholangiopathy (i.e., Caroli disease) is very uncommon but has been reported [8].…”

Section: Discussionmentioning

confidence: 99%

“…The characteristic finding on biopsy in AIDS cholangiopathy is prominent mucosal folds which indicate inflammation and edema. This mucosal thickening can be diffuse or it can be focal in which case it is fine and nodular [9]. Approximately 26% of patients with AIDS cholangiopathy have AIDS-related polypoid cholangitis which consists of intraluminal polypoid defects within the common bile duct and the larger intrahepatic ducts.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

AIDS Cholangiopathy in an Asymptomatic, Previously Undiagnosed Late-Stage HIV-Positive Patient from Kenya

Gao

Chin

Mishriki

2011

International Journal of Hepatology

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AIDS-associated cholangiopathy is a form of biliary tract inflammation with stricture formation seen in AIDS patients who are severely immunosuppressed. It is no longer common in countries in which HAART therapy is widely employed but is still seen in underdeveloped countries. The majority of patients are symptomatic at the time of presentation. Herein, we describe a seventy-four-year-old woman who presented with unilateral leg swelling after a prolonged airplane flight. She was otherwise entirely asymptomatic. Routine laboratory testing was notable for a hypochromic microcytic anemia, slight leukopenia, and mild hypoalbuminemia. Liver enzymes were all elevated. Deep venous thrombosis was confirmed, and a CT scan of the chest disclosed no pulmonary emboli. However, the visualized portion of the abdomen showed dilatation of the common bile and pancreatic ducts. This was confirmed on ultrasonography and MRCP, and no obstructive lesions were noted. An ERCP revealed a dilated common bile duct without filling defects or strictures. A balloon occlusion cholangiogram showed strictures and beading of the intrahepatic ducts. Shortly thereafter, serology for HIV returned positive along with a depressed CD4 cell count, and the patient was diagnosed with AIDS-associated cholangiography.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%