Isolated intracranial rosai-dorfman disease: report of 2 cases and a review of the literature

Abdel-Razek, Mamdouh; Matter, Ghazi Ahmed; Azab, Waleed A.; Katchy, K.C.; Mallik, A.A.

doi:10.5137/1019-5149.jtn.4275-11.2

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Rosai-Dorfman disease is an uncommon disorder that rarely involves CNS, moreover, multiple intracranial lesions have also been seldom reported. As indicated in previous studies, this specific type of RDD has a propensity to occur in males (male : female 3.3 : 1) and the age of patients at diagnosis ranges from 2 to 72 years [1,4,7,8,10,13,16,20,[25][26][27][31][32][33]35,[38][39][40][41]44,48,51,53,55] (Table II). Presenting symptoms associated with neurological deficits and mass effects depend on the location, size, and growth pattern of lesions.…”

Section: Discussionmentioning

confidence: 63%

Clinicopathological characteristics of multiple intracranial Rosai-Dorfman disease with increased IgG4-positive plasma cells: a report of two cases

Zhou¹,

Ren²,

Liu³

et al. 2021

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Rosai-Dorfman disease (RDD) is an uncommon condition characterized by the proliferation of histiocytes and multiple intracranial involvements and it is extremely rare. Here, we present two cases of multiple intracranial RDD mimicking meningioma. These patients underwent surgery for tumour resection and pathological findings revealed an increased number of IgG4-positive plasma cells in RDD. The radiographic appearance and histology may contribute to a diagnostic dilemma, and immunohistochemical and serological examinations are a necessary complement for definitive diagnosis. Treatment protocols pertaining to such types of RDD cases are reviewed. Currently, surgical resection is the most effective therapy, and steroid therapy, radiotherapy, or chemotherapy may be provided as adjuvant treatments in some selected patients.

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Section: Discussionmentioning

confidence: 63%

Clinicopathological characteristics of multiple intracranial Rosai-Dorfman disease with increased IgG4-positive plasma cells: a report of two cases

Zhou¹,

Ren²,

Liu³

et al. 2021

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“…According to 285 RDD literature reviewed cases [1][2][3][4][5]7,9,10,[12][13][14][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][33][34][35][36][37][38][39]41,[44][45][46][47][48][50][51][52][53][54][56][57][58][59][60][61][62]…”

Section: Discussionmentioning

confidence: 99%

“…[76,96] On RDD, in addition, on contrast-enhanced T1-weighted images with gadolinium, the lesions are markedly enhanced, homogeneously or inhomogeneously, and the dural tail sign can commonly be found. [1,47,56,94,150,184,187,196,201] Recently, new MRI sequences have been recommended for the diagnosis of RDD, such as diffusion tensor imaging (DTI), susceptibilityweighted imaging, and perfusion-weighted imaging, [71,77] in addition, the use of 18F-FDG PET/CT has been described to diagnose relapsed intracranial RDD of the hypothalamus in a patient. [39] MRI spectroscopy meningiomas have been shown to have elevated Cho and decreased NAA, which is also seen in many other neoplastic processes, decrease in Cr and prominent Ala, much more so than in other neoplastic processes and is considered a spectroscopic signature for meningiomas.…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review

Tatit

Raffa²,

Motta

et al. 2021

Surgical Neurology International

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Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytic proliferative disorder classically as a massive cervical lymphadenopathy. However, over the years, extranodal locations were confirmed with the central nervous system involvement in less than 5% of cases, which is marked as a significant differential diagnosis of meningiomas, with which they are widely confused due to the similarity of their radiological images. Case Description: We report a 37-year-old man and 45-year-old man who were diagnosed with intracranial RDD but whose radiological images mimic meningiomas, requiring anatomopathological and tumor’s immunohistochemistry for definitive diagnosis. Moreover, a review of 184 publications with 285 cases of intracranial involvement of this disease was also performed, comparing these findings with those brought in the previous studies. Conclusion: Intracranial Rosai-Dorfman tumors should always be remembered as differential diagnosis of meningiomas since they are similar radiologically and macroscopically. Once remembered and diagnosed, the lesion must be treated following the same pattern of resection done in meningiomas and, treatment’s differences will not occur in the surgical excision technique, but in complementary chemotherapy implementation, radiotherapy, and even with radiosurgery aid, depending on the case. Thus, it is possible to obtain better results than with just the isolated surgical procedure.

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“…8,22,23 When the disease arises in the lymph nodes, the collagen capsule thickens and becomes fibrotic, and the subcapsular sinus expands. Patients with RDD often experience fever, fatigue, night sweats, and other such generalized symptoms.…”

Section: Discussionmentioning

confidence: 99%

Is it a Metastatic Disease

Liu

Wang²,

Yang³

et al. 2016

The American Journal of Dermatopathology

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Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder, whose etiology remains unclear. Most patients experience a limited clinical course followed by recovery; however, a small subset of patients show persistence over years, with death occurring in a few cases because of multiorgan involvement. About 40% of patients have extranodal manifestations, with skin and meninges being the main extranodal sites. Cutaneous involvement occurs in approximately 10% of cases; however, RDD seldom affects the skin alone. In this study, the authors report the case of a 58-year-old woman who first presented with a cutaneous mass on the left inner thigh, then on the right wrist, and on the right chest area for the third time. She was misdiagnosed with nonspecific inflammatory disease at the first and second subcutaneous lesions. After the third excision surgery, the patient was diagnosed with RDD based on the hematoxylin and eosin stain and immunohistochemical staining results. The authors retrospectively reviewed the tissue slides from the previous 2 surgeries; interestingly, all the 3 tissue specimens demonstrated similar morphological features. Some RDD cells were observed in the walls of blood vessels in the tissue, with some invasion in the lumen of the vessels; therefore, the authors inferred that the second and third occurrences of RDD in locations different from the first-time lesion were caused by the vascular invasion of RDD cells from the first-time lesion.

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Isolated intracranial rosai-dorfman disease: report of 2 cases and a review of the literature

Cited by 5 publications

References 19 publications

Clinicopathological characteristics of multiple intracranial Rosai-Dorfman disease with increased IgG4-positive plasma cells: a report of two cases

Clinicopathological characteristics of multiple intracranial Rosai-Dorfman disease with increased IgG4-positive plasma cells: a report of two cases

Rosai-Dorfman disease mimicking images of meningiomas: Two case reports and literature review

Is it a Metastatic Disease

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