Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome

Karisola, Piia; Kotovuori, A.; Poikonen, S.; Niskanen, Einari A.; Kalkkinen, Nisse; Turjanmaa, Kristiina; Palosuo, Timo; Reunala, Timo; Alenius, Harri; Kulomaa, Markku S.

doi:10.1016/j.jaci.2004.09.015

Cited by 30 publications

(18 citation statements)

References 37 publications

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“…Isolation, characterization and cloning of the main allergens involved in cross-reactivity between pollen and food enabled the study of the homology between pollens and plant foods [9,10]. In addition, this advance has led to the introduction of purified allergens as a diagnostic aid, defined as ‘component-resolved diagnostics’ [11].…”

Section: Introductionmentioning

confidence: 99%

Plant Food Allergy in Patients with Pollinosis from the Mediterranean Area

Flores

Cervera²,

Sánz

et al. 2012

Int Arch Allergy Immunol

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Background: Patients with pollinosis develop symptoms after intake of plant food more often than the general population. In order to study the prevalence of the presentation of allergic symptoms to plant foods in pollinosis, we selected a representative sample of the population from our Mediterranean area. Methods: All patients completed a questionnaire, provided a blood sample and underwent a battery of skin and other complementary tests (prick-prick, oral challenge test) when necessary. The pollen counts were obtained from the Elche pollen station. In addition, sera from a subgroup of patients were checked with an allergen molecule panel on an Advia Centaur XP platform. Results: Of the final sample (n = 233), 39.9% of the patients with pollinosis were sensitized and 30.9% had clinical allergy to at least one of the plant foods studied. Regression analysis showed that age and sensitization to the extracts of Platanus acerifolia and Artemisia vulgaris were the most important variables for discriminating between groups. Patients with pollinosis at a risk of allergy to plant foods had significantly higher Pru p 3 values [odds ratio (OR) 3.3; 95% confidence interval (95% CI) 2.3–4.8], and the value increased according to the number of plant food sensitizations. Conclusion: Plant food allergy is more common in patients with pollinosis than in the general population. The use of the London plain tree (P. acerifolia) and mugwort (A. vulgaris) in the skin tests may help identify such patients in our Mediterranean area, but determination of rPru p 3 could also be very useful in patients suspected of having plant food allergy.

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Section: Introductionmentioning

confidence: 99%

Plant Food Allergy in Patients with Pollinosis from the Mediterranean Area

Flores

Cervera²,

Sánz

et al. 2012

Int Arch Allergy Immunol

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“…The hevein isoform Hev b 6.0202, with only a single mutation (Asn14Asp), shows decreased IgE-binding capacities, along with pseudo-hevein [46,138]. Several other epitope studies confirmed that indeed the hevein epitope is conformational [96,133,138,142]. In addition, Hev b 6.01, 6.02 and 6.03 are able to stimulate peripheral blood mononuclear cell (PBMC) proliferation in allergic patients [92,98] and Hev b 6.01 was also shown to induce pro-inflammatory cytokines (TNF, IL-12p40, IL-13) and chemokine (CCL3, 4 and 20) expression [97].…”

Section: Allergenicitymentioning

confidence: 99%

“…Hevein, along with Hev b 5, is amongst the main allergens for HCW wearing latex gloves [90,131,132]. Hevein-like peptides may also be involved in spina bifida (SB) and latex-fruit or vegetable syndrome, an associated hypersensitivity to some plant-derived foods which develops via allergenic cross-reactivity [132][133][134][135][136][137]. Prohevein and hevein are recognized to be major latex allergens [36,62,95], and along with the C-ter domain they have all been shown to be allergenic to various degrees.…”

Section: Allergenicitymentioning

confidence: 99%

Highlights on Hevea brasiliensis (pro)hevein proteins

2016

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“…latex Hev b 11 [37], and plant food allergens such as avocado Pers a 1 and chestnut Cas s 5 cross-react with the major latex allergen hevein [38,39]. Further, there are some evidences that class I chitinases from cherimoya, passion fruit, kiwi, papaya, mango, and tomato display IgE cross-reactivity with hevein [40], although the catalytic domains of these allergens showed comparably low IgE binding activities [41].…”

Section: Pr-3 Family or Class I Chitinasesmentioning

confidence: 99%

Molecular Properties of Plant Food Allergens: A Current Classification into Protein Families

Hauser¹,

Egger²,

Wallner³

et al. 2008

TOIJ

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So far the allergen list of the International Union of Immunological Societies (IUIS) allergen nomenclature subcommittee comprises 130 plant-derived food allergens. Based on sequence homology these allergens can be classified into only 27 out of 9,000 known protein families according to the Allfam database. These families comprise the prolamin and cupin superfamilies, pathogenesis related proteins, profilins, thaumatin-like proteins, oleosins, expansins, a number of enzymes and protease inhibitors among others. The classification on structural and thus biochemical and functional similarities will provide a new outlook on the molecules and might contribute to answer the question about allergenicity of different proteins. This will help to define clinical relevant allergenic molecules and explain cross-reactive phenomena between single food allergen sources as well as between food allergens and allergenic molecules of other origins (e.g. pollen).

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Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome

Cited by 30 publications

References 37 publications

Plant Food Allergy in Patients with Pollinosis from the Mediterranean Area

Plant Food Allergy in Patients with Pollinosis from the Mediterranean Area

Highlights on Hevea brasiliensis (pro)hevein proteins

Molecular Properties of Plant Food Allergens: A Current Classification into Protein Families

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