Isolated hepatic tuberculosis: An uncommon presentation of a common culprit

Shastri, Minal; Kausadikar, Shripad; Jariwala, Jigar; Dave, Dhaval; Patell, Rushad

doi:10.4066/amj.2014.2076

Cited by 6 publications

(9 citation statements)

References 10 publications

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“…The overall treatment duration of this case was six months, and is in agreement with other reports from the world [8,9]. However, some experts recommend an extension of 9-12 months treatment plan for HTB [4,13], and we argued that, the prolonged approach is more suitable for adults, in contrast to children, where treatment outcomes are generally good and they tolerate the anti-TB drugs better than adults. Moreover, the World Health Organization guidance recommended that both pulmonary and extra-pulmonary disease should be treated with the same regimens lasting 6 months, and at least 9-12 months treatment plan for TB meningitis, TB of bones or joints [14].…”

Section: Discussionsupporting

confidence: 89%

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

Muftah¹,

Mathouq²,

Zain³

2016

SJMCR

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Hepatic Tuberculosis (HTB) is a rare form of tuberculosis. The disease presentation and characteristics have been described in a number of adult cases from low resource settings, however, little is known about the disease in children. We report a case of 9-year-old boy who had a prolonged history of fever. His clinical data were nonspecific. Laboratory and imaging data were not helpful. We did laparoscope biopsy of liver and histopathological study was done, which showed chronic granulomatous inflammation. He diagnosed as Hepatic Tuberculosis and received anti tuberculosis therapy; his condition got better. The age of our case indicates that the disease can infrequently occur in children in contrast to what is written in literature.

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Section: Discussionsupporting

confidence: 89%

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

Muftah¹,

Mathouq²,

Zain³

2016

SJMCR

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“…They are often managed with modified liver-friendly antitubercular regimens for fear of increasing the hepatotoxicity and causing acute liver failure with the use of standard regimen. Few case reports are available in literature reporting the use of the modified regimens 11 , 12 . We believe such cases are underreported, and firm guidelines have not been established to guide clinicians in these cases.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Pulmonary tuberculosis and raised transaminases without pre-existing liver disease- Do we need to modify the antitubercular therapy?

et al. 2020

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We report a case of an adult female with pulmonary tuberculosis who had biochemical evidence of liver injury during the presentation manifested as raised transaminases, but without clinically obvious pre-existing liver disease nor a history of hepatotoxic drug use. This is a fairly common scenario seen in tuberculosis endemic areas; however, this is an under reported condition in the literature and guidelines for its management has not been established. Many clinicians including the authors have treated such cases with modified liver friendly regimens in fear of increasing the hepatotoxicity with standard antitubercular drugs. However, the modified regimens may not be optimal in treating the underlying tuberculosis. In this report, we gave full dose standard drugs, and the liver injury resolved as evidenced by normalization of transaminases. Further research is required in this regard, but the presence of transaminitis with no obvious common underlying etiology may not warrant a modification of standard antitubercular regimen.

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“…Similarly, isolated hepatic tuberculosis presenting as jaundice and abdominal distension has been reported in literature by Shastri et al . [ 9 ] However, hepatic TB presenting as acute liver failure has not been reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic tuberculosis presenting as acute liver failure

Jain

Aggarwal

Jain

et al. 2014

Oxford Medical Case Reports

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Abdominal tuberculosis is a common clinical entity in Indian subcontinent; however, hepatic tuberculosis in the absence of miliary abdominal tuberculosis is restricted to the case reports and small case series in English literature. It mimics common liver diseases like liver abscess and tumors. We report a case of 25-year-old immunocompetent female who presented with features of acute liver failure. Ultrasonography (USG) abdomen revealed multiple hypoechoic lesions. However, patient expired within 48 h of presentation but her liver autopsy revealed multiple epithelioid cell caseating granulomas with positive staining for acid fast bacilli (AFB). Polymerase chain reaction (PCR) was also positive for Mycobacterium tuberculosis.

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Isolated hepatic tuberculosis: An uncommon presentation of a common culprit

Cited by 6 publications

References 10 publications

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

Case Report: Pulmonary tuberculosis and raised transaminases without pre-existing liver disease- Do we need to modify the antitubercular therapy?

Primary hepatic tuberculosis presenting as acute liver failure

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