Isolated Granulocytic Sarcoma of the Breast after Allogeneic Stem Cell Transplantation: A Rare Involvement Also Detected by 18FDG-PET/CT

Gündüz, Eren; Akay, Meltem Olga; Karagülle, Mustafa; Ak, İlknur

doi:10.4274/tjh.2012.0106

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…Sometimes there is bilateral first presentation, also with multiple masses [9, 11, 15, 18, 21, 25, 30, 32, 36, 39, 45, 48, 50, 51]. Around 40% (21 cases) of the patients had a previous diagnosis of acute myeloid leukemia [17, 18, 21, 23, 24, 39, 40, 43, 47, 48], and among those cases, seven had undergone bone marrow transplant [25, 26, 33, 38, 43, 48]. Interestingly, Obiorah and Ozdemirli [43] reported a case of post-transplant MS arisen in a patient with ET history evolved into myelofibrosis with no evidence of dysplasia or increased blast cell count.…”

Section: Discussionmentioning

confidence: 99%

Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review

et al. 2022

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Introduction: Myeloid sarcoma (MS) is a mass-forming proliferation of myeloid blasts. Frequently, it arises as blast phase of pre-existing myeloproliferative, myelodysplastic disorders or consequent to bone marrow transplant. Its molecular characterization has become an increasingly important requirement for the diagnostic definition of this solid leukemia. Case Presentation: Our case report concerns an MS arising in the breast of a woman with a previous diagnosis of JAK2-mutated essential thrombocythemia (Val617Phe exon 14p) mimicking, on histology, a lobular carcinoma of the breast. The immunohistochemical study of the neoplasm provided the key that solved the diagnostic doubt and the immunohistochemical evaluation of NPM protein expression, which turn out to be negative, provided a clear indication on the molecular status and prognosis of the disease. A year later, the neoplasm relapsed in the pelvic area. Discussion: This diagnostic challenge led us to review the literature of the past 10 years concerning MS of the breast. To the best of our knowledge, this was the first case of MS of the breast occurring in a patient with a history of essential thrombocythemia and recurred in the pelvic region.

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Section: Discussionmentioning

confidence: 99%

Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review

et al. 2022

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“…Some reports clearly specified a hamartoma-like appearance when describing the sonographic features [2,16]. Furthermore, across a vast number of reports, the internal echotextures of breast myeloid sarcoma were found to be at least heterogeneous [2–4,12–16,20–24,26,27,30,35,36].…”

Section: Discussionmentioning

confidence: 99%

Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Kim

2019

Am J Case Rep

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Patient: Female, 24 Final Diagnosis: Myeloid sarcoma of the breast Symptoms: Breast lump Medication: — Clinical Procedure: Core needle biopsy Specialty: Radiology Objective: Rare disease Background: Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before, concurrently with, or following acute myeloid leukemia presentation. Few reports have focused on the imaging findings in cases of myeloid sarcoma of the breast, and the existing findings are variable and nonspecific; the present case report aimed to bridge this gap. Case Report: A 24-year-old female presented with a palpable lump at the upper outer quadrant of her right breast. She had noticed the mass 2 days prior to presentation. She was first diagnosed with acute myelogenous leukemia 18 months before the lump presentation and had undergone haploidentical stem cell transplantation 6 months prior. At the time of the breast lump presentation, she was undergoing chemotherapy for relapsed acute myeloid leukemia. Ultrasonography of her right breast revealed a circumscribed, oval mass corresponding to the palpable lump. Ultrasonography-guided 14-gauge core needle biopsy was performed on the breast mass, leading to a pathological diagnosis of myeloid sarcoma. Conclusions: We reported a case of myeloid sarcoma involving the breast. On sonography, although the internal echotexture resembled that of breast hamartoma, the observed hard elasticity and high vascularity raised suspicions of malignancy.

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“…GS develops in 9% of patients with acute myeloid leukemia [1] and occurs in 5% to 7% of patients undergoing allogeneic hematopoietic stem cell transplantation as a relapse. [2] Only approximately 20 cases of pancreatic GS have been reported. [3–15] In almost all cases, CT and/or magnetic resonance imaging were performed, whereas the 18 F-FDG PET/CT findings remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Granulocytic sarcoma of the pancreas on 18F-FDG PET/CT

Ishii

Kondo²,

Oka³

et al. 2016

Medicine

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Rationale:Granulocytic sarcoma (GS) is defined as leukemia infiltration in any organ other than the bone marrow. GS rarely occurs in the pancreas. Here, we present the first report of GS in the pancreas on 18F-fluorodexyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).Patient concerns:A 19-year-old male patient with acute myeloid leukemia received a human leukocyte antigen-haploidentical stem cell transplant as a second transplant while in second complete remission.Interventions:After a second stem cell transplant, obstructive pancreatitis accompanied by a mass in the pancreatic head was observed. FDG-PET/CT revealed abnormal activity in the head of the pancreas and the skin in the patient's left breast area.Diagnoses:Pathological examination demonstrated relapsed acute myeloid leukemia in both the lesions.Outcomes:This is the first report showing the 18F-FDG PET/CT findings of GS in the pancreas.Lessons:18F-FDG PET/CT may help determine the stage of GS.

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Isolated Granulocytic Sarcoma of the Breast after Allogeneic Stem Cell Transplantation: A Rare Involvement Also Detected by 18FDG-PET/CT

Cited by 13 publications

References 14 publications

Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review

Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review

Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Granulocytic sarcoma of the pancreas on 18F-FDG PET/CT

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