Isolated Fetal Sinus Bradycardia as a First Sign of Congenital Hypopituitarism

Abstract

We present a case of marked fetal sinus bradycardia as the sole presenting sign of congenital combined pituitary hormone deficiencies. Fetal sinus bradycardia < 120 beats/min was detected at 36 weeks of gestation during an otherwise uncomplicated pregnancy. Sinus bradycardia persisted after birth, and congenital hypothyroidism and growth hormone deficiencies were subsequently identified. Normal sinus rhythm was rapidly restored with hormone supplementation. Hypothyroidism and growth hormone deficiency should be considered in the differential diagnosis of unexplained perinatal sinus bradycardia because early diagnosis may help to avoid potential complications (ie, mental retardation, severe hypoglycemia, and growth anomaly).

Application and Clinical Analysis of Remote Fetal Heart Rate Monitoring Platform in Continuous Fetal Heart Rate Monitoring Images

“…In the method of calculating the fetal heart rate, the researchers used a relatively simple method, that is, calculating the time interval between two fetal heart signal peaks and further calculating the number of peaks within one minute to represent the fetal heart rate. Relevant scholars use the time window method [19][20][21]. First, they calculate the number of crests in a fixed-length time window and then calculate the number of windows within one minute and multiply it by the number of crests to express the fetal heart rate.…”