Isolated eyelid edema in Melkersson–Rosenthal syndrome: a case series

Abstract

Monosymptomatic patients with MRS require a high index of suspicion. Histopathological confirmation is vital for the diagnosis.

Re ‘Isolated eyelid edema in Melkersson–Rosenthal syndrome: a case series’

“…1 Nevertheless, the clinico-pathological pattern that we and other authors have ascribed to monosymptomatic MRS appears quite distinct. Until our understanding of the etiology and pathogenesis of oro-facial granulomatosis, of which MRS is one part, increases, we see no justification for regarding these cases as a form of granulomatous rosacea.…”

“…4 Indeed, acne rosacea and Melkersson-Rosenthal syndrome have some overlap in their clinical and pathological features and both are classified as granulomatous dermopathies. The illustrations of Cases 1 and 2 in the series of Rawlings et al 1 show facial features that would be consistent with acne rosacea, with rhinophymatous change and thickened glabellar skin. I suspect these two illustrated patients do indeed have acne rosacea rather than Melkersson-Rosenthal syndrome, and it would be of interest to know whether any of the other three patients in the series also showed features of rosacea.…”

“…Sir, Re 'Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series ' Rawlings et al 1 have reported on a series of five patients with isolated eyelid edema and have made the diagnosis of Melkersson-Rosenthal syndrome on the basis of granulomatous inflammation. Melkersson-Rosenthal syndrome is described as a granulomatous disease with the triad of facial palsy, facial edema, and a fissured tongue, although the complete triad is reported to be seen in only 25% of cases.…”

Orbital inflammatory disease management

“…Treatment for MRS leading to eyelid edema typically involves corticosteroids, and resolution of edema has been reported with both intralesional and systemic administration [225][226][227][228][229], although improvement is often short-lived given the relapsing and remitting nature of the disease.…”

“…Within the orbit and adnexa, MRS usually presents with upper and lower eyelid edema [224][225][226][227][228][229].…”