Isolated esthesioneuroblastoma of sphenoid sinus

Sharma, Suresh C.; Reddy, C. Ekambar Eshwara; Srinivasan, Srinivasan S.; Rawal, Ajay; Singh, Dipender P.

doi:10.1053/ajot.2001.26500

Cited by 21 publications

(22 citation statements)

References 6 publications

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“…Up to date, there are nine cases reported as an esthesioneuroblastoma outside the cribriform plate, including five cases in sellar region [5][6][7][8][9], three cases in sphenoid sinus [4,10,11], and another one was not available in clinical detail (Table 1). Hormonal abnormalities and visual deficits served as the main clinical presentations in those five cases of the sellar region which suprasellar extension was common in.…”

Section: Discussionmentioning

confidence: 99%

“…The development of an esthesioneuroblastoma outside to the region in which olfactory epithelium exists is extremely rare [4]. Up to date, there are nine cases reported as an esthesioneuroblastoma outside the cribriform plate, including five cases in sellar region [5][6][7][8][9], 3 cases in sphenoid sinus [4,10,11], and another one not available in clinical detail. None of them presented as CSF rhinorrhea and chronic meningitis.…”

Section: Objectivementioning

confidence: 99%

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A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures

2008

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The development of an esthesioneuroblastoma outside to the region in which olfactory epithelium exists is extremely rare. Only nine cases were reported in the previous literatures. The author presents a 40 years-old man with ectopic esthesioneuroblastoma in sella turcica. In contrast to the previous nine cases, our case presented unusual presentations-CSF rhinorrhea and meningitis. Endoscopic transphenoid approach with removal of tumor and repair of dura defect followed by radiotherapy offered a good result in this case. Moreover, differential diagnosis and the origin of the ectopic esthsioneuroblastoma would be discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Objectivementioning

confidence: 99%

A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures

2008

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“…Only six cases of ENB isolated to the sphenoid sinuses have been described in the literature to date. [5][6][7] One case had an unusual metastasis to the skin of the sternal region. [8,9] Several theories exist as to the origin of ENB in locations where olfactory neuroepithelium is not thought to exist.…”

Section: Discussionmentioning

confidence: 99%

Sphenoidal esthesioneuroblastoma treated with sequential chemo radiotherapy: A case report and review of the literature

Abdel‐Rahman

Kamal

2014

J Can Res Ther

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Esthesioneuroblastoma (ENB)-also known as olfactory neuroblastoma-originates primarily from the olfactory epithelium in the roof of the nasal cavity. We present here the 7th reported case of ENB arising from the sphenoidal sinus. We undertook a review of the case notes from the time of initial presentation and literature review of this topic. A 55-year-old male presented with a 3-year history of unilateral progressive nasal obstruction, epistaxis, difficult nasal-breathing, facial pain, frontal headache and blood-tinged discharge. Nasal examination revealed a glistening mass in right nasal cavity. Endoscopy-assisted transnasal excision was performed. Histologically, tumor was identified as small round cell tumor and confirmed by immunohistochemistry to be olfactory neuroblastoma (negative leucocyte common antigen, positive neurone specific enolase). Sphenoidal ENB is rare in the literature, and this presentation is the 7th reported case; in addition, surgical treatment is very challenging, and non-surgical treatment is used most commonly.

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“…In particular, a broad panel of antibodies in immunohistochemical staining is necessary to verify the diagnosis. ENB is usually positive for general neuroendocrine markers, such as NSE, S-100 protein, Syn and chromogranin [7] . In this study, we found that the tumors were more frequently positive immunoreactivity to NSE and Syn than others.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Esthesioneuroblastoma

Zhang¹,

Zhou²,

Wang³

et al. 2010

ORL

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Aims: Our purpose was to evaluate the diagnosis and combined modality treatment of esthesioneuroblastoma treated at 1 institution. Methods: A retrospective analysis of clinical information regarding presentation, immunohistochemical results, treatment and outcome was performed on 21 patients with esthesioneuroblastoma. Results: Two patients had Kadish A, 12 had Kadish B and 7 had Kadish C disease. The mean follow-up was 41.9 months. Immunohistochemical stains were performed in 17 cases, and the tumors were focal positive or showed positive immunoreactivity to neuron-specific enolase (17/17, 100%), synaptophysin (13/17, 76.5%), S-100 protein (8/17, 47.1%), epithelial membrane antigen (5/17, 29.4%), chromogranin A (4/17, 23.5%), vimentin (3/17, 17.6%) and cytokeratin (2/17, 11.8%). Generally, the patients were treated with preoperative radiotherapy (Kadish A and Kadish B) and preoperative chemoradiotherapy (Kadish C) after the initial biopsy, followed by surgery. Surgical approaches (n = 21) consisted of 12 lateral rhinotomies, 5 craniofacial resections, 3 endoscopic sinus surgeries and 1 midfacial degloving approach. The 5-year crude overall survival rate was 76.2%. Conclusions: Esthesioneuroblastoma is an uncommon malignant tumor. Thorough histological evaluation is the key to correct diagnosis and differentiation. Preoperative radiotherapy or chemoradiotherapy can give surgeons the chance to choose different surgical approaches, especially the endoscopic surgical techniques, in the future.

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Isolated esthesioneuroblastoma of sphenoid sinus

Cited by 21 publications

References 6 publications

A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures

A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures

Sphenoidal esthesioneuroblastoma treated with sequential chemo radiotherapy: A case report and review of the literature

Diagnosis and Management of Esthesioneuroblastoma

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