Isolated elevation of serum alkaline phosphatase level in an uncomplicated pregnancy: A case report

Markedly elevated serum alkaline phosphatase level in an uncomplicated pregnancy

“…Placental isozyme activity has the longest half-life of all the alkaline phosphatase isozymes with *7 days. The second one is the liver isozyme with a half-life of 3 days and the last one is bone with 1-2 days [2,4]. In respect to the origin of alkaline phosphates and clinical course, our case has showed similarity with the first three of the abovementioned cases.…”

“…Significantly elevated alkaline phosphatase activity in the last trimester of pregnancy has been reported in only five cases. In the first report [2,3] the alkaline phosphatase activity increased due to placental isozyme. There was 15% placental infarction but this minor degree of placental infarction is seen frequently; therefore, this did not explain significant elevation of the alkaline phosphatase activity.…”

Placental exosomes in normal and complicated pregnancy

“…6,10 PLAP is an integral membrane protein (enzyme) of the placenta (it has also been observed in some gynecologic cancers), produced mainly by syncytiotrophoblast. 22,23 Nevertheless, PLAP expression has been found in primary trophoblast cytotrophoblast cells 10 and ED27 trophoblast-like cells, both isolated from first-trimester chorionic villi, and in JEG-3 cells (an extravillous trophoblast model). 24 In addition, using immunohistochemistry for PLAP, the majority of chorionic trophoblastic cells were positive for PLAP.…”

A case of isolated peripartum elevation of alkaline phosphatase in pregnancy complicated by gestational diabetes

“…The predominant isoenzyme of AP was that of bone type, rather than the expected elevation of placental isoenzyme that has previously been reported [1,[3][4][5]. No obvious bone or metabolic disease has been noted in the postpartum period.…”