Isolated dysphagia due to paraneoplastic myasthenic syndrome with anti-P/Q-type voltage-gated calcium-channel and anti-acetylcholine receptor antibodies

Fernández‐Torrón, Roberto; Arcocha, Juan; López-Picazo, José M.; Pardo, Javier; Tamura, Maria Akiko; Carretero, Cristina; Pástor, Pau

doi:10.1016/j.nmd.2010.10.003

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…The onset of the disease usually occurs around 40 years of age, but it can occur at any age. It is characterized by a clinical triad that consists of proximal muscle weakness, neurovegetative disorders and decreased tendon reflexes 8 (all present in this case). Pharyngeal muscles are involved in LES only in 7% of patients, with presence of dysphagia 8 (as in this case).…”

Section: Discussionmentioning

confidence: 90%

“…It is characterized by a clinical triad that consists of proximal muscle weakness, neurovegetative disorders and decreased tendon reflexes 8 (all present in this case). Pharyngeal muscles are involved in LES only in 7% of patients, with presence of dysphagia 8 (as in this case). Neoplasms, mainly small cell lung carcinoma, are present in 50-60% of LES cases.…”

Section: Discussionmentioning

confidence: 90%

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Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Arellano-Aguilar

Núñez-Mojica

Gutiérrez-Velazco

et al. 2019

CIRUE

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Background: Neurological paraneoplastic syndromes are rare, occur in 0.01% of all cancer patients; like part of them, the Lambert-Eaton syndrome is an autoimmune presynaptic disorder of neuromuscular transmission characterized by muscle weakness and neurovegetative dysfunction, and often associated with small cell lung cancer. Case report: A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg. Physical examination: patient prostrated; clinical muscle examination: pelvic muscles waist −3/5 and −4/5 the rest; diminished reflexes. Laboratory normal parathormone and hypercalcemia. With electrophysiological study and positive anti-voltage-gated calcium channel antibodies, confirming Lambert-Eaton syndrome and imaging studies with neoplastic condition in brain, liver and kidney, with unspecified primary origin.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Arellano-Aguilar

Núñez-Mojica

Gutiérrez-Velazco

et al. 2019

CIRUE

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“…El inicio de la enfermedad suele presentarse alrededor de los 40 años, pero puede ocurrir a cualquier edad. Se caracteriza por la tríada clínica de debilidad muscular proximal, trastornos neurovegetativos y disminución de los reflejos tendinosos 8 (todos presentes en el caso). Los músculos faríngeos se ven involucrados en el SLE solo en el 7% de los pacientes, presentando disfagia 8 (como en este caso).…”

Section: Discussionunclassified

Síndrome paraneoplásico de Lambert-Eaton en paciente con cáncer metastásico diseminado

Arellano-Aguilar¹,

Núñez-Mojica²,

Gutiérrez-Velazco³

et al. 2019

CIRU

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A 72 years old female with a family history of lung cancer and leukemia, with 7 months of dry cough and 3 months with waist and pelvic muscle weakness, oropharyngeal dysphagia, dry mouth, chronic constipation and weight loss of 10 kg. Physical examination: patient prostrated; clinical muscle examination: pelvic muscles waist -3/5 and -4/5 the rest; diminished reflexes. Laboratory normal parathormone and hypercalcemia. With electrophysiological study and positive anti-voltage-gated calcium channel antibodies, confirming Lambert-Eaton syndrome and imaging studies with neoplastic condition in brain, liver and kidney, with unspecified primary origin.

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“…Of patients diagnosed with LEMS the incidence of SCLC in studies ranges from around 40% to 62%. 1 , 17 – 20 Tumor associated LEMS (T-LEMS) is almost entirely due to SCLC; other tumors have been reported in association with LEMS (for example non-small-cell lung cancer, 1 prostate cancer, 21 and thymoma 22 , 23 ) but these are likely to represent incidental findings. The incidence of T-LEMS is greatest in men over 50; 24 – 26 in non-tumor LEMS (NT-LEMS) there are two peaks in incidence, at 35 and 60 years, with a female preponderance in the lower age group and broadly equal sex distribution in the older group.…”

Section: Clinical Featuresmentioning

confidence: 99%

The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinoma

Briggs

Gozzard

Talbot

2013

ITT

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Lambert–Eaton myasthenic syndrome (LEMS) is an autoimmune disorder mediated by autoantibodies to voltage-gated calcium channels. The disorder is diagnosed clinically on the basis of a triad of symptoms (proximal muscle weakness, hyporeflexia, and autonomic disturbance), supported by electrophysiological findings and the presence of autoantibodies. Between 40% and 62% of patients diagnosed with LEMS are found to have small-cell lung cancer (SCLC), almost all of whom develop neurological symptoms before their cancer is diagnosed. Prompt identification of LEMS and appropriate screening for SCLC is key to improving the outcome of both conditions. Here we review the pathophysiology and clinical management of LEMS, focusing particularly on the relationship with SCLC.

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Isolated dysphagia due to paraneoplastic myasthenic syndrome with anti-P/Q-type voltage-gated calcium-channel and anti-acetylcholine receptor antibodies

Cited by 9 publications

References 9 publications

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Síndrome paraneoplásico de Lambert-Eaton en paciente con cáncer metastásico diseminado

The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinoma

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Isolated dysphagia due to paraneoplastic myasthenic syndrome with anti-P/Q-type voltage-gated calcium-channel and anti-acetylcholine receptor antibodies

Cited by 9 publications

References 9 publications

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Paraneoplastic Lambert-Eaton syndrome in a patient with disseminated metastatic cancer

Síndrome paraneoplásico de Lambert-Eaton en paciente con cáncer metastásico diseminado

The association between Lambert&ndash;Eaton myasthenic syndrome and small cell lung carcinoma

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The association between Lambert–Eaton myasthenic syndrome and small cell lung carcinoma