Isolated cutaneous epithelioid hemangioendothelioma

Polk, Peggy; Webb, James L. A.

doi:10.1016/s0190-9622(97)80297-6

Cited by 25 publications

(8 citation statements)

References 10 publications

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“…Primary presentation in the skin is rare 13 . Cutaneous lesions may be associated with subsequent bone, 14,15 lymph node and pulmonary lesions 16 or present without systemic involvement 17–20 . Although originally classified as a low‐grade malignant vascular tumour, hence the designation haemangioendothelioma, this tumour was upgraded as fully malignant due to a metastatic rate of between 20 and 30% and a mortality rate between 10 and 20% 10–12 .…”

Section: Vascular Tumours Of Intermediate Malignancy (Low‐grade Maligmentioning

confidence: 99%

“…Although originally classified as a low‐grade malignant vascular tumour, hence the designation haemangioendothelioma, this tumour was upgraded as fully malignant due to a metastatic rate of between 20 and 30% and a mortality rate between 10 and 20% 10–12 . Interestingly, in comparison with those arising in the viscera and deep soft tissue, primary cutaneous lesions have a low local recurrence rate and metastatic potential and may represent a biologically distinct subset of EHE 13,17–20 …”

Section: Vascular Tumours Of Intermediate Malignancy (Low‐grade Maligmentioning

confidence: 99%

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Cutaneous vascular tumours: an update

Goh

Calonje

2008

Histopathology

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This review evaluates changes in vascular nomenclature particularly in the category of vascular tumours of intermediate malignancy that includes the various haemangioendotheliomas, Kaposi's sarcoma and giant cell angioblastoma. Recently described entities in this category, including the latter tumour and composite haemangioendothelioma, are described. Several newly characterized vascular tumours not included in recent classifications of vascular tumours are also summarized. These include acquired elastotic haemangioma, symplastic haemangioma, cutaneous epithelioid angiomatous nodule and cutaneovisceral angiomatosis with thrombocytopenia. The newly introduced clinical classification of congenital haemangiomas into non-involuting and rapidly involuting variants and radiation-induced atypical vascular lesions are also reviewed.

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Section: Vascular Tumours Of Intermediate Malignancy (Low‐grade Maligmentioning

confidence: 99%

Section: Vascular Tumours Of Intermediate Malignancy (Low‐grade Maligmentioning

confidence: 99%

Cutaneous vascular tumours: an update

Goh

Calonje

2008

Histopathology

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“…In the skin, it seems that this neoplasm usually arises from a medium‐sized or large vein, mainly in the superficial or deep soft tissue, and only approximately 10% of the cases arise from superficial dermal vessels of the skin or mucous membranes . Although the clinical presentation of EHE may be variable, the neoplasm in the skin usually presents as a solitary, rarely multiple, erythematous papule, nodule, plaque, or hyperkeratotic or nonhealing ulcer that may subsequently extend to the underlying tissues, including the bone. In most cases the signs and symptoms of EHE are nonspecific and consist of a painful or tender mass or a slowly growing tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Epithelioid hemangioendothelioma (EHE) is a low‐grade, malignant, vascular neoplasm first described in 1982 by Weiss and Enzinger . It mostly presents as a solitary, slightly painful soft‐tissue tumor, although it has also been identified in the skin . EHEs occur without sex preference and at any age, although most described cases developed in adults (ages 30–50 yrs), and they are extremely uncommon during childhood, with only five infantile cases reported to date .…”

mentioning

confidence: 99%

Cutaneous Epithelioid Hemangioendothelioma on the Sole of a Child

Carranza-Romero

Molina-Ruiz

Monroy

et al. 2015

Pediatric Dermatology

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Epithelioid hemangioendothelioma (EHE) has been considered to be a low-grade malignant vascular neoplasm, although follow-up of recent series has demonstrated that EHE involving the skin and soft tissues should be better regarded as a fully malignant vascular tumor since it has more metastatic potential than previously thought. We report a case of an EHE involving the left sole of 6-year-old boy, the youngest patient with cutaneous EHE described to date. Immunohistochemical studies demonstrated a lymphatic endothelial line of differentiation for neoplastic cells. Cutaneous EHE is rare in childhood, with only five previously described cases.

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“…However, tumors with focal spindling of cells, necrosis, mitotic activity and cytologic atypia tend to pursue a more aggressive course. 11 It seems that only a high mitotic rate (>6 mitotic figures per 10 high-power fields) correlates clearly with poor prognosis. 5 The local recurrence rate of EHE was reported to be 13%, the metastasis rate was 31%.…”

Section: Discussionmentioning

confidence: 99%

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

Ma¹,

Xu³

et al. 2010

Neuropathology

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Epithelioid hemangioendothelioma (EHE) is a rare and low-grade vascular tumor, which usually occurs in the soft tissue, liver, breast, lung and skeleton. Here we submit a case with EHE of the clival region. A 58-year-old woman was admitted with a medical history of 3 months headache and 1 month visual deterioration. MRI revealed a well-circumscribed mass of 4.0 cm × 3.0 cm with bony invasion. The tumor was subtotally removed in a piecemeal fashion. Histologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and intracytoplasmic vacuoles. Immunohistochemically, the tumor cells were positive for the markers CD31, CD34, factor VIII and vimentin. The pathological result was interpretated as EHE of the clival region. EHE is an uncommon vascular tumor, which is rarely seen in the clival region. Definitive diagnosis depends on histopathologic and immunohistochemical features.

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Isolated cutaneous epithelioid hemangioendothelioma

Cited by 25 publications

References 10 publications

Cutaneous vascular tumours: an update

Cutaneous vascular tumours: an update

Cutaneous Epithelioid Hemangioendothelioma on the Sole of a Child

Primary epithelioid hemangioendothelioma in the clival region: A case report and literature review

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