Isolated Corticotropin Deficiency in Adults

Yamamoto, Taro; Fukuyama, Jiro; Hasegawa, K.; Sugiura, Masahiko

doi:10.1001/archinte.1992.00400200131024

Cited by 38 publications

(10 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principle signs and symptoms associated with isolated ACTHdeficiency are variable, non-specific and similar to those seen in adrenocortical insufficiency due to other causes (8). The present patient showed the typical symptomsof isolated ACTHdeficiency, such as general malaise, gastrointestinal symptoms, the loss of mental activity, and hypotension (8,9). However, other endocrinological disorders such as thyroid dysfunction or hypoglycemia, which frequently occur in association with this disease, were not found.…”

Section: Discussionmentioning

confidence: 45%

Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency.

et al. 1996

View full text Add to dashboard Cite

A 64-year-old manwas referred to our hospital for evaluation of progressive anemia. On admission, he had a severe normocytic normochromic anemia [hemoglobin 7.5 g/dl] requiring a blood transfusion. Endocrinological studies demonstrated an isolated ACTHdeficiency. After receiving glucocorticoid replacement therapy, his anemia was rapidly corrected, his hematocrit and hemoglobin remained elevated for approximately 4 months. Wepresent evidence that glucocorticoid plays an important role in the physiological regulation of humanerythropoiesis. (Internal Medicine 35: 898-901, 1996)

show abstract

Section: Discussionmentioning

confidence: 45%

Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency.

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Isolated ACTH deficiency is a secondary adrenal insufficiency that may become life-threatening [3,4]. Only ACTH among six anterior pituitary-hormones is not secreted.…”

Section: Discussionmentioning

confidence: 99%

“…Isolated ACTH deficiency is a cause of secondary adrenocortical insufficiency [3,4]. Conspicuous symptoms of IAD are severe general malaises, appetite loss and weakness reflecting adrenal insufficiency and joint stiffness is also considered to be related to IAD [5].…”

Section: Introductionmentioning

confidence: 99%

Isolated ACTH deficiency in self referred patients for LOH syndrome: two case reports

Sato

Tanda

Nakajima

et al. 2012

Reprod Medicine & Biology

View full text Add to dashboard Cite

We experienced two cases of isolated ACTH deficiency (IAD) in patients self referred for late-onset hypogonadism (LOH) syndrome. IAD is secondary adrenal insufficiency due to lack of secretion of ACTH and delayed diagnosis of this rare condition may be life-threatening. The predominant symptoms of IAD, such as general malaise and weakness, resemble those of LOH syndrome creating the possibility that IAD may be referred as LOH syndrome. Two middle aged men with severe general malaise visited our clinic requesting evaluation for LOH syndrome. Previous treatments had been ineffective and based on varying incorrect diagnoses by previous doctors. The patients self referred themselves for LOH syndrome. Some of their symptoms were consistent with LOH syndrome but others were atypical, in particular, the severity of malaise and appetite loss. Hormonal assays were compatible with adrenal insufficiency secondary to ACTH deficiency. Steroid replacement dramatically improved their symptoms. The clinical course of our two patients and points of differential diagnosis between IAD and LOH syndrome are reported here.

show abstract

“…However, increased thyroid‐stimulating hormone (TSH) levels were reported in 45 of 76 patients recently reviewed. 25 The hypersecretion of TSH is not due to a decrease in negative feedback, since these patients do not have subnormal levels of thyroid hormones, but may instead result from increased production of its hypothalamic secretagogue thyrotropin releasing hormone (TRH). While TRH itself does not affect ACTH secretion, we hypothesized that another peptide derived from the preproTRH precursor and co‐released with TRH could have CRIF activity.…”

Section: Preprotrh 178‐199 As a Putative Crifmentioning

confidence: 99%

A Novel Endogenous Corticotropin Release Inhibiting Factor

Redei

Rittenhouse

Revskoy

et al. 1998

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

ACTH is the major regulator of the body's adaptive response to stress and the physiological stimulus for glucocorticoid secretion. A hypothalamic corticotropin release inhibiting factor (CRIF) that inhibits ACTH synthesis and secretion has long been postulated but was not characterized until recently. We have recently identified a 22 amino acid peptide, prepro-thyrotropin releasing hormone (TRH) 178-199 that inhibits basal and stimulated ACTH synthesis and secretion in vitro and stress-induced ACTH secretion in vivo. Prepro-TRH 178-199 is abundant in several brain regions, including the external zone of the median eminence, where its concentration changes in response to stress. We propose that this peptide is a physiological regulator of ACTH production: an endogenous CRIF. Because prepro-TRH 178-199 is encoded within the same precursor as TRH, its expression is likely to be negatively regulated by thyroid hormones leading to changes in endogenous glucocorticoid levels. Streptococcal cell wall (SCW)-induced inflammation, a model of rheumatoid arthritis (RA), was alleviated after long-term thyroxine treatment. Inversely, a hypothyroid milieu led to decreased basal hypothalamic-pituitary-adrenal activity, but increased expression of IL-1 beta and MIP-1 alpha, specific markers for RA in humans. These results suggest that this putative CRIF may be an important component in the development of RA and that regulation of prepro TRH may be highly relevant to the development of other autoimmune diseases that are also exacerbated by low endogenous glucocorticoid levels.

show abstract

Isolated Corticotropin Deficiency in Adults

Cited by 38 publications

References 78 publications

Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency.

Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency.

Isolated ACTH deficiency in self referred patients for LOH syndrome: two case reports

A Novel Endogenous Corticotropin Release Inhibiting Factor

Contact Info

Product

Resources

About