Isolated Cardiac Metastasis from Squamous Cell Esophageal Cancer

Abbate, Maria Ida; Cicchiello, Federica; Canova, Stefania; Cortinovis, Diego; Mariani, Silvia; Maffini, Fausto; Bidoli, Paolo

doi:10.5301/tj.5000324

Cited by 9 publications

(6 citation statements)

References 11 publications

(13 reference statements)

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“…In total, 164 cases (out of 147 articles) [6–153] of unexpected ECM were selected to establish our database. The following data elements were extracted from each article: author name, publication year, article type, patient sex, age at diagnosis, histological type of cancer, tumor location in the esophagus, stage at diagnosis, management of primary tumor, site of metastases, metastasis features (solitary, multiple, synchronous, metachronous, and onset after initial tumor diagnosis), management of metastases, outcomes, and survival.…”

Section: Methodsmentioning

confidence: 99%

Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Shaheen

Ghibour

Alsaid

2017

Gastroenterology Research and Practice

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The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. On the other hand, unexpected metastasis (UM) spread to uncommon sites has increasingly reported and consequently affected the pathway of diagnosis, staging, and management. Using the PubMed database, a systematic search of the following headings “Esophageal” and “Metastasis” or “Metastases” was performed, 10049 articles were identified, and the articles were included if they demonstrated unexpected ECM. 84% of cases were men with an average age of 60.7 years. EC was located in the lower third in 65%. Two-thirds of the UM originated from the lower esophagus, and the two major histological types were adenocarcinoma 40% and squamous cell carcinoma 60%. Metastases were disseminated toward five main anatomical sites: the head and neck (42%), thoracic (17%), abdomen and pelvis (25%), extremities (9%), and multiple skin and muscle metastases (7%). The EC metastases were found to be synchronous 42% and metachronous 58%, isolated in 53.5% and multiple in 46.5%. The overall survival rate was 10.2 months. Since distant metastases are responsible for most EC-related deaths, understanding of ECM dissemination patterns needs more extensive studies. These critical data are the cornerstone of optimal cancer approach and treatment.

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Section: Methodsmentioning

confidence: 99%

Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Shaheen

Ghibour

Alsaid

2017

Gastroenterology Research and Practice

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“…In all, 12 cases were solitary cardiac metastases. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Most of the cardiac metastasis are detected on autopsy studies. These studies reported the incidence of cardiac metastasis was 2.3%-18.3% of cancer patients and 0.2%-6.5% of unselected autopsy series.…”

Section: Discussionmentioning

confidence: 99%

“…According to the past 15 reports of cardiac metastasis from esophageal cancer, the median time from the detection of primary tumor to the onset of cardiac metastasis was 8.9 months. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] The differential diagnosis of cardiac mass is difficult. In case of a cardiac tumor, metastasis is more frequent than a primary tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 15 reports with cardiac metastasis from esophageal cancer, surgical resection was performed in three cases (20.0%). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Whether or not surgical removal of cardiac metastasis contributes to prognostic prolongation is totally unknown due to lack of clinical evidence. However, it should not be missed that surgical resection can prevent pulmonary embolism because certain size of mass, whether it is a thrombus or a tumor, can cause pulmonary embolism.…”

Section: Discussionmentioning

confidence: 99%

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Solitary Cardiac Metastasis from Esophageal Cancer

Akabane

Urabe

Ohkura

et al. 2023

ATCS

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A 72-year-old woman with past medical history of rectal cancer resection (adenocarcinoma, pT3N1aM0) presented with a 2-month history of dysphagia. Imaging studies found a thoracic esophageal cancer, for which subtotal esophagectomy with gastric conduit reconstruction via retrosternal route followed by chemoradiotherapy were performed (squamous cell carcinoma, pT4N1M0, RM1). Seven months after the esophagectomy, a contrast-enhanced computed tomography (CT) demonstrated a new asymptomatic mass inside the right atrium. A thrombus or a tumorous lesion was suspected. Positron emission tomography (PET)/CT showed abnormal uptake in the mass. After a thorough discussion by a multidisciplinary oncology group, we performed 1-week anticoagulant therapy first, resulting in mass enlargement. Then tumorectomy was carried out. The final pathological findings revealed that the mass was squamous cell carcinoma, yielding the diagnosis of cardiac metastasis from esophageal cancer. The patient’s postoperative course was unremarkable. PET/CT may help to estimate malignancy and to omit invasive heart surgery.

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“…[ 1 ] What is more, cardiac metastatic tumors are often asymptomatic that they are found only at autopsy and seldom be reported. [ 2 ] Mainly malignant melanoma and primary mediastinal tumors, but also lymphoma, lung carcinoma, breast, esophagus, and leukemia, are cause of cardiac metastases. [ 3 ] In case of cardiac metastatic tumors, the prognosis is poor and therapeutic options limited.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and treatment of right ventricular metastasis from esophageal squamous cell carcinoma: An unusual case report and a literature review

Luo,

Luo

2023

Medicine

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Background: Right ventricular metastasis from esophageal squamous cell carcinoma is very rare and only seen in few case reports. Patients with cardiac metastasis have a poor prognosis with a median survival period of 4 weeks due to the lack of standardized and effective treatment guidelines. Therefore, we aimed to clarify the feature and treatment of cardiac metastasis through literature review and reporting of an unusual case. Case: We reported a case of a 67 years-old man diagnosed as right ventricular metastasis from esophageal squamous cell with the help of echocardiography and pathological biopsy. Moreover, the patient survival period reached an astonishing 6 months, which far exceeded 4 weeks reported in previous literature. Methods: We searched for relevant literature in the past decade on PUBMED and summarized the content of the literature to better clarify cardiac metastasis. Conclusion: Cardiac metastatic likely to occur in the elderly and in the right side of heart which related to hemodynamics. Surgical resection of metastatic tumors is the main treatment method, but patients usually die during the perioperative period due to its complexity and difficulty. Meanwhile, we have proposed some potentially effective treatment measures.

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Isolated Cardiac Metastasis from Squamous Cell Esophageal Cancer

Cited by 9 publications

References 11 publications

Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Solitary Cardiac Metastasis from Esophageal Cancer

Diagnosis and treatment of right ventricular metastasis from esophageal squamous cell carcinoma: An unusual case report and a literature review

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