Isolated brain metastases prior to locoregional recurrence in hilar cholangiocarcinoma

Abstract

Abstract. Isolated brain metastases prior to locoregional recurrence from hilar cholangiocarcinoma (HCCA) following curative resection are an extremely rare event. Very few reports regarding brain metastasis prior to locoregional recurrence following curative resection have been published due to the fact that to differentiate brain metastases from HCCA recurrence is challenging, particular in the early stages, since the neurological findings of brain metastasis are occult and subtle. Any patient with HCCA who has undergone radical resection and subsequently presented with a further onset of neurological symptoms should be evaluated for brain involvement. The present case study describes a patient with HCCA who underwent curative resection, and experienced isolated brain metastases prior to locoregional recurrence.

Highly specific determination of IDH status using edited in vivo magnetic resonance spectroscopy

“…Indeed, IDH mutations affect a few neoplasms, mainly myeloid hemopathies, which do not form brain tumors, and 2 rare solid tumors, chondrosarcomas and cholangiocarcinomas, for which brain metastases are extremely rare and which are characterized by a very different radiological presentation from diffuse gliomas. 25,26 The spectral analysis of all edited MRS data acquired in gliomas of subjects who were negative for the IDH1 or IDH2 mutations, as well as in healthy tissue, provided concentrations of 2HG <0.2 mM with CRLB = 999%, while for the subjects with IDH mutations 2HG was >0.6 mM and CRLB <50% for all but one subject (S07, CRLB = 273%). With the exception of S07, a net separation between 2 subgroups of subjects (those with detectable 2HG with CRLB <999% and those with nondetectable 2HG and CRLB = 999%) was established.…”

Unveiling the unprecedented – Very late brain metastasis in cholangiocarcinoma: A case report and comprehensive analysis

“…The median duration between the diagnosis of cancer and the identification of brain metastases was 13.6 months (ranging from 7.3 to 52.8). [4] Here, we present an unusual case of a 79-year-old male with a remarkable history of distal CCA who presented with neurological symptoms indicative of brain metastasis. The rarity of such occurrences emphasizes the complexity of CCA metastatic behavior and the need for careful monitoring in long-term survivors.…”

“…The median duration between the diagnosis of cancer and the identification of brain metastases was 13.6 months (ranging from 7.3 to 52.8). [ 4 ]…”

Very rare metastatic phenomena of biliary tract cancer to the cerebellum: A case report and review of the literature

“…The precise incidence of brain metastases (BMs) originating from BTC remains largely uncertain. Limited information is available, with only a handful of individual case reports and two sets of cases that have detailed these BMs from BTC [ [5] , [6] , [7] , [8] , [9] , [10] ]. According to the most recent case series, the occurrence rate of BTC-related BMs stands at 1.4 % [ 6 ].…”