Isolated atrioventricular canal defects: Birth outcomes and risk factors: A population‐based hungarian case–control study, 1980–1996

Vereczkey, Attila; Kósa, Zsolt; Csáky-Szunyogh, Melinda; Czeizel, Andr̀ew E.

doi:10.1002/bdra.23124

Cited by 18 publications

(15 citation statements)

References 48 publications

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“…All of the studies were published between 1989 and 2013. There were 14 case–control studies [28] – [41] and 3 cohort studies [42] – [44] . The main characteristics of the included studies are presented in Table S1 .…”

Section: Resultsmentioning

confidence: 99%

“…In the 3 cohort studies, cohort sizes varied from 22,365 [44] to 1,625,945 [43] , and the number of CHD cases ranged from 4,123 [44] to 12,101 [43] . In the 16 case–control studies, the number of cases varied from 81 [28] to 7,575 [32] , and the number of control subjects ranged from 302 [39] to 38,151 [41] . The highest parity number ranged from 2 [28] to more than 4 [39] .…”

Section: Resultsmentioning

confidence: 99%

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Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Feng

Chen

et al. 2014

PLoS ONE

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BackgroundEpidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted.MethodsWe searched MEDLINE and EMBASE for articles catalogued between their inception and March 8, 2014; we identified relevant published studies that assessed the association between maternal parity and CHD risk. Two authors independently assessed the eligibility of the retrieved articles and extracted data from them. Study-specific relative risk estimates were pooled by random-effects or fixed-effects models. From the 11272 references, a total of 16 case-control studies and 3 cohort studies were enrolled in this meta-analysis.ResultsThe overall relative risk of CHD in parous versus nulliparous women was 1.01 (95% CI, 0.97–1.06; Q = 32.34; P = 0.006; I2 = 53.6%). Furthermore, we observed a significant association between the highest versus lowest parity number, with an overall RR = 1.20 (95% CI, 1.10–1.31; (Q = 74.61, P<0.001, I2 = 82.6%). A dose–response analysis also indicated a positive effect of maternal parity on CHD risk, and the overall increase in relative risk per one live birth was 1.06 (95% CI, 1.02–1.09); Q = 68.09; P<0.001; I2 = 80.9%). We conducted stratified and meta-regression analyses to identify the origin of the heterogeneity among studies. A Galbraith plot was created to graphically assess the sources of heterogeneity.ConclusionIn summary, this meta-analysis provided a robust estimate of the positive association between maternal parity and risk of CHD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Feng

Chen

et al. 2014

PLoS ONE

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“…The body of literature searched on the subject identified 26 studies which examined SES in relation to CHD development as listed in Table 1. The majority of the studies (18/26, 69%) examined individual maternal SES variables and the risk of CHD [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level [38][39][40][41], and still others (4/26, 15%) examined the individual, family and neighborhood SES to weigh the relative contribution of each level of the SES variables in CHD development [42][43][44][45].…”

Section: Resultsmentioning

confidence: 99%

“…Education was the variable most commonly assessed in these studies and the findings were largely inconclusive with some reporting associations between maternal education and CHD [21,[26][27][28] and others finding no associations [25,29,30]. Low skilled occupations and low income similarly were associated with CHD in some studies [22,26,32,33,37] and not in others [20,23,24,30,31]. In the United States, Egbe et al reported interesting findings on the relationship between income and CHD, where they documented an increased incidence of mild CHD among Caucasian populations in the upper quartiles of SES [34][35][36] compared to non-Caucasian minority populations.…”

Section: Advances In Pediatric Researchmentioning

confidence: 94%

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Ngwezi¹,

Hornberger²,

Osornio-Vargas³

2018

apr

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Introduction: Congenital heart disease (CHD) is the most common congenital anomaly affecting 1% of all live births of which the etiology remains unknown. The incidence is higher in developing countries likely related to low literacy, poverty and higher exposures to hazardous environmental nuisances. The role of socioeconomic status (SES) in CHD development has recently received attention. To gain the breadth of knowledge generated from existing publications, we undertook a scoping review of studies examining the relationship between SES and CHD. Methods: We searched databases using individual or combination of keywords which included non-Medical Subject Heading (non-MeSH) and MeSH terms. We included original observational studies using cohort, case control or ecologic study designs written in English and from 1980-2017. Results: We identified 26 studies, most of which were conducted in developed economies with very few from developing economies. The majority (18/26, 69%) examined individual maternal SES variables and the risk of CHD, whilst fewer (4/26, 15%) examined associations with SES at the area level or neighborhood level and others (4/26, 15%) examined the individual, family and neighborhood SES levels to weigh the relative contribution of each SES level in CHD development. Individual maternal low education and low skilled occupation were associated with CHD in half of the studies and another half of the studies found no associations between these variables and CHD. Evidence regarding the influence of neighborhood SES alone or multiple SES variables has been inconclusive as well. Conclusion: There is a paucity of studies from both developed and even more so from developing countries that have examined the influence of SES in CHD development. More knowledge regarding the contribution of various SES measures (i.e., individual, area level, and combinations) on CHD occurrence is required before relevant and effective interventions can be implemented.

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“…Thus, the objective of our project was to differentiate CHD entities and evaluate their possible risk factors 9 10. As the recently proposed CHD classifications are based on pathogenesis rather than anatomic location,11–13 we followed the CHD categorization in the Baltimore-Washington Infant Study 12.…”

Section: Introductionmentioning

confidence: 99%

Maternal hypertension with nifedipine treatment associated with a higher risk for right-sided obstructive defects of the heart: a population-based case-control study

Csáky-Szunyogh¹,

Vereczkey²,

Gerencsér

et al. 2014

Heart Asia

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Isolated atrioventricular canal defects: Birth outcomes and risk factors: A population‐based hungarian case–control study, 1980–1996

Cited by 18 publications

References 48 publications

Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

Maternal Parity and the Risk of Congenital Heart Defects in Offspring: A Dose-Response Meta-Analysis of Epidemiological Observational Studies

The role of socioeconomic status and the development of congenital heart disease: A scoping review

Maternal hypertension with nifedipine treatment associated with a higher risk for right-sided obstructive defects of the heart: a population-based case-control study

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