Isolated antibody to hepatitis B core antigen in patients with chronic hepatitis C virus infection

Helmy, Ahmed; Al-Sebayel, Mohammed

doi:10.3748/wjg.v12.i27.4406

Cited by 18 publications

(25 citation statements)

References 21 publications

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“…A significant association was found between the presence of HBV DNA and anti-HCV positivity. In agreement with our results, studies by Jilg et al [44] and Helmy et al [45] revealed a high correlation between anti-HCV and hepatitis B core antibodies. Because HBV and HCV have similar transmission models, co-infection of both viruses is expected to be common.…”

Section: Discussionsupporting

confidence: 94%

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Helaly¹,

Ghazzawi²,

Shawky³

et al. 2015

Journal of Infection and Public Health

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The prevalence of end-stage renal disease has increased dramatically in developing countries. Hepatitis B virus (HBV) infection is a global health problem that represents a significant co-morbidity event that has led to outbreaks of hepatitis B. There are inadequate data concerning occult HBV infection among Egyptian chronic hemodialysis patients. This study aimed to detect occult HBV infection among chronic hemodialysis patients in Alexandria, Egypt. A cross-sectional study was performed on 100 patients with end-stage renal disease that received maintenance hemodialysis and had tested negative for HBV surface antigen. Blood samples were collected before the initiation of hemodialysis. Sera were tested for hepatitis C virus (HCV) and hepatitis B core (HBc) antibodies using ELISA, and HBV DNA was detected by SYBR Green real-time PCR using specific primers for the s and c genes and by nested PCR using pol gene-specific primers. The serum activity of alanine and aspartate aminotransferase (ALT and AST) were also measured. Anti-HCV and anti-HBc antibodies were detected in 34% and 48% of patients, respectively, and 70.6% of anti-HCV positive patients were also positive for anti-HBc antibodies. This association was statistically significant (p=0.001). HBV DNA was detected in 32% of the hemodialysis patients. A significant association was determined between the presence of HBV DNA and anti-HCV positivity (p=0.021). Aminotransferases were elevated in 21% of the studied patients, more often in patients with positive anti-HCV profiles than in patients negative for anti-HCV (p<0.05). In conclusion, the serological markers of HBV infection should be verified with molecular tests to investigate possible occult infections, especially among anti-HBc-positive hemodialysis patients, to improve our understanding of their clinical, laboratory, and epidemiological characteristics.

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Section: Discussionsupporting

confidence: 94%

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Helaly¹,

Ghazzawi²,

Shawky³

et al. 2015

Journal of Infection and Public Health

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“…Serologic detection of hepatitis B core antibodies is common in hepatitis B surface antigen-negative patients with chronic hepatitis C. 23 In agreement with our results, studies by Helmy et al 28 and Jilg et al 29 found a high correlation between anti-HCV and hepatitis B core antibodies. Because HBV and HCV have similar transmission models, coinfection of both viruses is expected to be prevalent.…”

Section: Discussionsupporting

confidence: 91%

Occult hepatitis B virus infection in Egyptian hemodialysis patients with or without hepatitis C virus infection

Ismail¹,

Soliman²,

Ismail³

2010

PLMI

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“…Although the seroprevalence of isolated anti-HBc in blood donors is 2% to 5%, the rates are significantly higher, ranging from 18.6% to 71%, among patients with chronic hepatitis C [14–16]. Two separate studies done in Saudi Arabia detected HBV DNA in 15.8% and 22.5% of HCV patients with isolated anti-HBc [14, 15]. …”

Section: Epidemiology Of Hbv/hcv Coinfectionmentioning

confidence: 99%

Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

2010

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Hepatitis B and hepatitis C are important causes of chronic liver disease globally. Although HBV/ HCV coinfection is not uncommon, its epidemiology is poorly defined. Numerous studies provided evidence that coinfection accelerates liver disease progression and increases the risk of hepatocellular carcinoma. By applying new cell culture models to examine the interaction of both viruses, investigators concluded that HBV and HCV replicate in the same hepatocyte without interference. The roles of innate and adaptive immunity in determining the viral replication and disease outcomes still need rigorous investigation. To date, no standard-of-care recommendation exists for HBV/HCV coinfection. Pegylated interferon and ribavirin combination therapy demonstrated similar efficacy in suppressing HCV RNA in coinfection and HCV monoinfection. However, HBV reactivation during therapy can be a challenge. Future clinical trials evaluating the addition of a nucleoside/nucleotide analog for selective patients with HBV/HCV coinfection are essential for successful management of HBV/HCV coinfection.

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Isolated antibody to hepatitis B core antigen in patients with chronic hepatitis C virus infection

Cited by 18 publications

References 21 publications

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Occult hepatitis B virus infection in Egyptian hemodialysis patients with or without hepatitis C virus infection

Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony

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