Isolated Adrenocorticotropic Hormone Deficiency not Always Permanent

Abstract

Isolated Adrenocorticotrophic hormone (ACTH) deficiency is rare but could be a lifethreatening condition characterized by hypocortisolism. Most causes are secondary to autoimmune process such as lymphocytic hypophysitis. It may also occur after traumatic brain injury, tumors, pituitary irradiation and ischemic brain insult. Genetic causes are not infrequent. We present two causes of Isolated Adrenocorticotrophic Hormone (ACTH) deficiency who experienced different outcomes and highlight the importance of understanding the various possible aetio-pathophysiology.