Isolamento e identificação molecular dos enterovírus não pólio em casos de paralisia flácida aguda, ocorridos na Região Norte do Brasil, no período de 1996 a 2006

Alves, Jainara Cristina dos Santos; Wanzeller, Ana Lucia Monteiro; Silveira, Edna da; Alves, Antonia dos Santos; Primo, Euda Galiza; Oliveira, Darleise de Souza; Linhares, Alexandre da Costa; Gomes, Maria de Lourdes Contente; Castro, Ceyla Maria Oeiras de

doi:10.5123/s2176-62232014000100004

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“…Surveillance data shows that in Europe, USA and Africa, most cases have been associated with EV-B species, whereas species A are normally more prevalent in Asia [13][14][15][16][17]. The etiology of AFP cases in Brazil is systematically determined, although information on molecular diversity and NPEV circulation patterns is still scarce [18].…”

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confidence: 99%

Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005–2017)

Sousa

Oliveira

Burlandy

et al. 2020

Emerging Microbes & Infections

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Due to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B > EV-A > EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs.

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