Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Belliotti, Thomas R.; Brink, Wouter A.; Kesten, Suzanne R.; Rubin, John R.; Wustrow, David; Zoski, Kim; Whetzel, Steven Z.; Corbin, A; Pugsley, Thomas A.; Heffner, Thomas G.; Wise, Lawrence D.

doi:10.1016/s0960-894x(98)00252-2

Cited by 202 publications

(113 citation statements)

References 20 publications

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“…The isoindolinone motif is not only a core structure in natural products such as daldinan A from the saprotrophic fungus Daldinia concentrica (Lee et al, 2012), stachybotrin C from the culture broth of Stachybotrys parvispora (Nozawa et al, 1997a;Nozawa et al, 1997b), lennoxamine from Berberis species (Fuchs and Funk, 2001), cichorine from Aspergillus silvaticus (Kawahara et al, 1988), fumaramidine from Fumaria parviflora (Hussain et al, 1981), and pestalachloride A from co-fermentation of a marine fungus and a marine bacterium (Li et al, 2008), but is also found in a number of pharmacologically relevant synthetic molecules such as (S)-PD 172938 (Belliotti et al, 1998), and ASK 186 (Kato et al, 1993;Lamblin et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

et al. 2015

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“…The present study applied the intravitreal injection approach, as used in chick, to tree shrews, mammals closely related to the primate line (Luckett, 1980). In addition, we used an agonist and antagonist that only bind the dopamine D4 receptor with high affinity (Glase et al, 1997; Belliotti et al, 1998; Clifford & Waddington, 2000; Gu et al, 2006). …”

Section: Introductionmentioning

confidence: 99%

Intravitreally-administered dopamine D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews

et al. 2017

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We examined the effect of intravitreal injections of D1-like and D2-like dopamine receptor agonists and antagonists and D4 receptor drugs on form-deprivation myopia (FDM) in tree shrews, mammals closely related to primates. In eleven groups (n = 7 per group), we measured the amount of FDM produced by monocular form deprivation (FD) over an 11-day treatment period. The untreated fellow eye served as a control. Animals also received daily 5 μL intravitreal injections in the FD eye. The reference group received 0.85% NaCl vehicle. Four groups received a higher, or lower, dose of a D1-like receptor agonist (SKF38393) or antagonist (SCH23390). Four groups received a higher, or lower, dose of a D2-like receptor agonist (quinpirole) or antagonist (spiperone). Two groups received the D4 receptor agonist (PD168077) or antagonist (PD168568). Refractions were measured daily; axial component dimensions were measured on day 1 (before treatment) and day 12. We found that in groups receiving the D1-like receptor agonist or antagonist, the development of FDM and altered ocular component dimensions did not differ from the NaCl group. Groups receiving the D2-like receptor agonist or antagonist at the higher dose developed significantly less FDM and had shorter vitreous chambers than the NaCl group. The D4 receptor agonist, but not the antagonist, was nearly as effective as the D2-like agonist in reducing FDM. Thus, using intravitreally-administered agents, we did not find evidence supporting a role for the D1-like receptor pathway in reducing FDM in tree shrews. The reduction of FDM by the dopamine D2-like agonist supported a role for the D2-like receptor pathway in the control of FDM. The reduction of FDM by the D4 receptor agonist, but not the D4 antagonist, suggests an important role for activation of the dopamine D4 receptor in the control of axial elongation and refractive development.

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“…1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 1H). 13 2-(4-methoxyphenyl)-3-(2-oxopropyl)isoindolin-1-one (5 q). [18] Brown solid, 70% yield, m.p.…”

Section: -(2-(4-methoxyphenyl)-2-oxoethyl)isoindolin-1-one (5 C)mentioning

confidence: 99%

Quaternary Ammonium Salt‐Promoted Multi‐Component Reaction in Water: Access to 3‐Alkyl‐2, 3‐Dihydro‐1H‐Isoindolin‐1‐One Derivatives

et al. 2016

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show abstract

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

Cited by 202 publications

References 20 publications

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

Intravitreally-administered dopamine D2-like (and D4), but not D1-like, receptor agonists reduce form-deprivation myopia in tree shrews

Quaternary Ammonium Salt‐Promoted Multi‐Component Reaction in Water: Access to 3‐Alkyl‐2, 3‐Dihydro‐1H‐Isoindolin‐1‐One Derivatives

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