Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum

Erinacene D, a new aromatic compound from Hericium erinaceum

“…Bioassay-guided isolation of the CHCl 3 fraction resulted in a new aromatic compound named erinacene D (1), together with six known compounds ( Figure 1). On the basis of spectral data and chemical evidence, which were consistent with previous reports, the structures of the known compounds were identified as hericene A (2), 7 hericene B (3), 7 hericene C (4), 7 hericenone C (5), 8 hericenone D (6) 8 and hericenone E (7). 8 In this study, we report the structural elucidation of erinacene D (1) and NF-kB inhibitory activity of compounds 1-7.…”

“…5 Isohericerin and isohericenone significantly reduce the viability of A549, SK-OV-3, SK-MEL-2 and HCT-15 cell lines. 6 In addition, hericenones C-E stimulated the synthesis of nerve growth factor (NGF) in vitro. 2 However, few reports have described their nuclear factor kappa B (NF-kB) inhibition.…”

Comparative studies on extracts from Hericium erinaceus by different polarity reagents to gain higher antioxidant activities

“…erinaceus is a notable mushroom with medicinal values; it contains various bioactive compounds with drug efficacy. The nutrients in H. erinaceus include herinase (23) and isohericenone (24). In the present study, eight reagents with nonpolar, weak, middle and strong polarity were used to extract the active compounds from H. erinaceus.…”

Sterols from Hericium erinaceum and their inhibition of TNF-α and NO production in lipopolysaccharide-induced RAW 264.7 cells

“…Hericeones, which are typical aromatic compounds of H. erinaceum, showed significant cytotoxicity against several cancer cell lines (Kim et al, 2012). They also promote nerve growth factor (NGF) synthesis (Kawagishi et al, 1991(Kawagishi et al, , 1993(Kawagishi et al, , 1994(Kawagishi et al, , 1996(Kawagishi et al, , 2006Ma et al, 2010).…”