Isogeneic Antiidiotype Repertoire and Modulation of Idiotype Expression in the Antidextran System

Weiler, Eberhardt; Lehle, Georg; Wilke, Joachim; Weiler, Ivan Jeanne

doi:10.1016/b978-0-12-417780-2.50016-2

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…(ii) Lack probably related to a direct interaction of anti-Id antibodies with the immunoglobulin receptor of B-cell clones as we demonstrated previously by an inability to transfer the suppression with T cells (27) and by the fact that the suppression was also obtained by using nude mice (28). Our data demonstrate that idiotype-mediated cross-reactive regulatiofi leads to cross-reactive iihibition of clones with different antigen specificities and that these CRI function as regulatory idiotopes (23).…”

Section: Discussionmentioning

confidence: 85%

Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.

Victor-Kobrin¹,

Manser²,

Moran³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 85%

Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.

Victor-Kobrin¹,

Manser²,

Moran³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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“…228 So entsteht eine spontane Binnenhierarchisierung des Rechts, die sich durch die Institutionalisierung rechtsprechender Instanzen verstärkt und beschleunigt, eine Form der Ver-dichtung des Rechtsstoffs, die traditionell für nationale Rechtsordnungen typischer war als für internationale. 229 Ein derart weites Verständnis von Konstitutionalisierung ermöglicht es, mit dem Begriff auch privatrechtliche Phänomene zu erfassen -namentlich scheint die Entwicklung des Common Law in seiner Amalgamierung von Privatrecht und "verfassungsrechtlichen Sicherungen" ein Konstitutionalisierungsphänomen darzustellen. 230 Für die im Vergleich zu allen anderen überstaatlichen Gebilden einzigartig weit fortgeschrittene Konstitutionalisierung der Europäischen Union ist die zentrale Rolle subjektiver Rechte der entscheidende Faktor, der sich aus der direkten Anwendbarkeit des Gemeinschaftsrechts 231 ergibt, die für eine intensive Vergerichtlichung des Unionsrechts sorgt.…”

Section: Bb)vorrang Des Vertragsrechtsunclassified

Verfassunggebende Gewalt – Verfassung – Konstitutionalisierung

Möllers

2009

Springer-Lehrbuch

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“…These antibodies are referred as anti-IdX reagent. Monoclonal anti-MOPC 104E idiotope antibodies were produced by a hybridoma cell line as described by E. Weiler et al; we used Hid 104E 1 cross-reacting with J558 and Hdexl4 [15].…”

Section: Anti-mopc 104e Id Reagentsmentioning

confidence: 99%

B cell dependence of the congeneic barrier towards idiotype‐carrying cells

1986

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Immune cells transferred into nonirradiated animals of the same genotype face a barrier which severely affects their capacity to function in the host. We studied this phenomenon in allotype-congeneic animals. When anti-dextran immune cells of the responder strain (BALB/c-Igha) are injected into an allotype-congeneic host (BALB-Ighb) the grafted cells are suppressed to give an idiotype-positive response. This congeneic barrier of thymus-independent immune cells is lost in mice carrying an X-linked B cell defect: when idiotype-positive immune cells from responder (CBA/N X BALB/c)F1 mice are transplanted into congeneic nonresponder animals (CBA/N X BALB-Ighb)F1, female recipients are nonpermissive towards grafted cells whereas B cell-defective male littermates allow donor cells to develop an idiotype-positive anti-dextran response. These results show that the congeneic barrier towards dextran-immune cells is related to the maturation stage of B cells in the recipient. Since B cell-defective (CBA/N X BALB/c)F1 animals do not display an anti-idiotypic response in contrast to intact littermates and because CB16-KN mice are nonpermissive towards CB8-K lymphocytes, differing in VH genes only, we suggest that the "isogeneic barrier" depends on a mechanism recognizing VH structures.

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Isogeneic Antiidiotype Repertoire and Modulation of Idiotype Expression in the Antidextran System

Cited by 7 publications

References 28 publications

Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.

Shared idiotopes among antibodies encoded by heavy-chain variable region (VH) gene members of the J558 VH family as basis for cross-reactive regulation of clones with different antigen specificity.

Verfassunggebende Gewalt – Verfassung – Konstitutionalisierung

B cell dependence of the congeneic barrier towards idiotype‐carrying cells

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