Isoform Dependent Functions of AUTS2 During Neuronal Differentiation

Rothkoff, Galya; Reisman, Marina; Tal, Nitzan; Shani, Odem; Nissim-Rafinia, Malka; Meshorer, Eran; Shifman, Sagiv

doi:10.1016/j.euroneuro.2016.09.401

Cited by 2 publications

(1 citation statement)

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“…Auts2 +/− ES cells have premature neuronal differentiation during in vitro corticogenesis resulting accelerated cell death of the Auts2 +/− corticoids. Mesodermal gene expression is also upregulated during this process [324]. These data suggest that Auts2 has a role in shifting ES cell proliferation to differentiation perhaps via selective interactions with the ncPRC1.3/1.5.…”

Section: Ncprc13 and Ncprc15mentioning

confidence: 81%

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

2018

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Originally two types of Polycomb Repressive Complexes (PRCs) were described, canonical PRC1 (cPRC1) and PRC2. Recently, a versatile set of complexes were identified and brought up several dilemmas in PRC mediated repression. These new class of complexes were named as non-canonical PRC1s (ncPRC1s). Both cPRC1s and ncPRC1s contain Ring finger protein (RING1, RNF2) and Polycomb group ring finger catalytic (PCGF) core, but in ncPRCs, RING and YY1 binding protein (RYBP), or YY1 associated factor 2 (YAF2), replaces the Chromobox (CBX) and Polyhomeotic (PHC) subunits found in cPRC1s. Additionally, ncPRC1 subunits can associate with versatile accessory proteins, which determine their functional specificity. Homozygous null mutations of the ncPRC members in mice are often lethal or cause infertility, which underlines their essential functions in mammalian development. In this review, we summarize the mouse knockout phenotypes of subunits of the six major ncPRCs. We highlight several aspects of their discovery from fly to mice and emerging role in target recognition, embryogenesis and cell-fate decision making. We gathered data from stem cell mediated in vitro differentiation assays and genetically engineered mouse models. Accumulating evidence suggests that ncPRC1s play profound role in mammalian embryogenesis by regulating gene expression during lineage specification of pluripotent stem cells.

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Section: Ncprc13 and Ncprc15mentioning

confidence: 81%

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

2018

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Research Investigation and Analysis on Behavioral Analytics, Neuro Imaging, and Pervasive Sensory Algorithms and Techniques for Autism Diagnosis

Sasikala

Sureshkumar

2019

Advances in Healthcare Information Systems and Administration

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Interdisciplinary research on autism diagnosis and training for the autistic children are current requirements. Behavioral analytics are the techniques followed by pediatricians for identifying ASD in children. However, the techniques successfully accepted by the pediatricians worldwide would be useful for the parents and pediatricians only for the elementary school-aged children, and the system is not helping for early diagnose among children of age 2. Machine learning, image processing, and pervasive techniques are trending for early diagnosis of ASD. Hence, the chapter has done a research-based survey and detailed analysis on behavioral analytics algorithms, neuro imaging, and eye tracking techniques for early diagnosis. The behavioral analytics survey mainly focuses on social and meta-cognitive skills, and the input dataset has been taken from parents, trainers, teachers, and peer groups. The chapter also identifies that computing technologies with neuro-imaging and pervasive techniques are better than the behavioral skill analysis for early diagnosis.

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Isoform Dependent Functions of AUTS2 During Neuronal Differentiation

Cited by 2 publications

References 0 publications

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

Research Investigation and Analysis on Behavioral Analytics, Neuro Imaging, and Pervasive Sensory Algorithms and Techniques for Autism Diagnosis

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