Isoflurane Minimum Alveolar Concentration Reduction by Fentanyl

McEwan, Angus; Smith, C. V.; Dyar, Oliver James; Goodman, David K.; Smith, L. R.; Glass, Psa

doi:10.1097/00000542-199305000-00009

Cited by 199 publications

(82 citation statements)

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“…On the other hand, fentanyl is a synthetic -opioid receptor agonist of the 4-anilinopiperidine series that is commonly used as an analgesic for moderate to serve pain in a number of species [17]. In humans and small animals, balanced anesthesia with fentanyl provides perioperative analgesia and improves hemodynamics by minimizing the necessary inhalation concentration of anesthetic agents for general anesthesia [11,12,23].…”

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confidence: 99%

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Ohta

Wakuno

Okada

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. To evaluate the effects of IV fentanyl administration on the end-tidal sevoflurane concentration (ET SEVO ) in thoroughbred racehorses, the ET SEVO required for internal fixation of longitudinal fractures was compared between horses anesthetized with sevofluranefentanyl (Group SF; n=9) and those anesthetized with sevoflurane alone (Group S; n=9). The loading dose of fentanyl (5.0 g/kg) was administered over 15 min followed by a maintenance dose of fentanyl (0.1 g/kg/min) throughout the operation in Group SF. The mean ET SEVO during the operation in Group SF (2.6  0.2%) was significantly lower than in Group S (3.0  0.3%). The plasma fentanyl concentrations (6.12  0.88 to 7.78  1.12 ng/ml) in 7 out of 9 horses in Group SF were stable and did not change significantly throughout the operation. The mean dobutamine infusion rate required for maintaining a mean arterial blood pressure between 60 and 80 mmHg during the operation in Group SF (0.56  0.30 g/kg/min) was significantly lower than in Group S (0.90  0.16 g/kg/min). The qualities of the recoveries were clinically acceptable, and serious complications were not observed in either group. In conclusion, continuous IV fentanyl administration reduced the sevoflurane requirement by 13% in thoroughbred racehorses undergoing orthopedic surgery; however, fentanyl was considered to be less effective in horses compared with other species.

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confidence: 99%

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Ohta

Wakuno

Okada

et al. 2010

The Journal of Veterinary Medical Science

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“…The context-sensitive half time is approximately three minutes and as this value does not change as the infusion duration increases the duration of effect of remifentanil is context-insensitive [10]. TCI fentanyl has been used for intraoperative analgesia in combination with isoflurane [11], sevoflurane [12] and propofol [13]. However, when used by infusion prolonged recovery can be a problem.…”

Section: Discussionmentioning

confidence: 99%

Effect-site Concentration of Alfentanil or Remifentanil for the Relief of Postoperative Pain in the Intensive Care Unit Patients

Jang¹,

Kang²

2015

International Journal of Contents

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“…A 50% reduction in MAC is realized with isoflurane when the plasma concentration of remifentanil is 1.37 ng/ml (Lang, et al, 1996). Fentanyl requires a slightly higher plasma concentration, 1.67 ng/ml, to attain this same reduction in isoflurane MAC (McEwan, et al, 1993).…”

Section: Pharmacodynamicsmentioning

confidence: 99%

Psychomotor Functioning: Comparison of Patients Recovering From General Anesthesia With Remifentanil and a Volatile Anesthetic Versus Fentanyl and a Volatile Anesthetic

Moseley¹

1998

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Isoflurane Minimum Alveolar Concentration Reduction by Fentanyl

Cited by 199 publications

References 0 publications

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Effect-site Concentration of Alfentanil or Remifentanil for the Relief of Postoperative Pain in the Intensive Care Unit Patients

Psychomotor Functioning: Comparison of Patients Recovering From General Anesthesia With Remifentanil and a Volatile Anesthetic Versus Fentanyl and a Volatile Anesthetic

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