Isoflurane in Paediatric Anesthesia

Hausdörfer, J.; Hagemann, H; Bell, Muyinatu A. Lediju; Mertinat, M.

doi:10.1007/978-3-642-71230-2_43

Cited by 3 publications

(2 citation statements)

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“…In contrast, the cardiovascular system was commonly affected, with bradycardia, hypotension, or both recorded in 37.5% of our cases. This incidence is much higher than the usual rate seen in the medical literature (23–26).…”

Section: Discussionmentioning

confidence: 58%

The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis

Rozentsveig

Katz

Weksler

et al. 2004

Pediatric Anesthesia

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Cardiovascular complications following anaesthesia are common in patients with the southern Israel variant of CIPA. Hyperthermia, previously recognized as a major concern in patients with congenital insensitivity to pain with anhydrous, was not seen in our patients. We conclude that cardiovascular involvement is frequently encountered in CIPA patients following anaesthesia and is the major concern in their anaesthetic management.

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Section: Discussionmentioning

confidence: 58%

The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis

Rozentsveig

Katz

Weksler

et al. 2004

Pediatric Anesthesia

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“…1-7) underwent cardiac surgery due to congenital heart defects, 5 patients (no. [8][9][10][11][12] were former preterm infants with a history of bronchopulmonary dysplasia and/or recurrent episodes of pulmonary arterial hypertension, 2 patients with severe sepsis (no. 13,15) and one (no.…”

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confidence: 99%

Observations on the Effects of Inhaled Isoflurane in Long-term Sedation of Critically Ill Children Using a Modified AnaConDa©-System

et al. 2013

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Long-term intravenous sedation may present problems due to dependence and side effects. Medical records of children who were administered isoflurane were reviewed. 15 patients (9 boys, 6 girls) with a mean age of 11.8 month (+2.4) were analysed.Analgesia and sedation was given in mean 9.7+1.1 days before commencing inhalation using a modified application device (AnaConDa©). Administration was given over a period of 7.2+1.4 days. Depth of sedation was monitored by using Comfort- and Hartwig-scores. Observations included continuous monitoring of heart-rate, pulse oxymetry, blood pressure and cerebral tissue oxygenation.Within 4 h post administration of isoflurane a satisfactory increase in the depth of sedation was seen and kept till extubation. 6/15 patients received tracheostomies during the observation period. None of the patients observed suffered life-critical events of the modified application of isoflurane proceeded without complications. Ketamine and clonidine infusion rates were significantly reduced (p<0.005) as well as the use and overall infusion rate of midazolam, γ-hydroxy butyrate, fentanyl and morphine (p<0.05).Isoflurane inhalation may provide an additional option for long-term sedation in a specific group of critically ill infants but neurodegenerative toxic effects will have to be taken into account when using volatile anesthetics at any time during infancy.

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The onset of ablation of the evoked adductor pollicis muscle twitch in children: a clinical perspective

1988

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The onset of ablation of the evoked adductor pollicis muscle twitch in children: a clinical perspectiveThe time to loss of the adductor pollieis muscle response to ulnar nerve stimulation at 1 Hz (twitch) after suceinylcholine, From the University of Michigan Medical Center, The Department of Anesthesiology, C.S. Matt Children's Hospital, Room C4139, Box 0800, Ann Arbor, MI 48109-0800.General anaesthesia is commonly induced in children by inhalation of an anaesthetic vapour in an oxygen/nitrous oxide mixture. Following induction of anaesthesia, an intravenous infusion is started and a muscle relaxant is administered to facilitate intubation and surgery. Previous work suggests that inhalation agents may affect the onset, potency, and duration of action of muscle relaxants. These conclusions have been based on studies which relied on controlled experimental conditions while measurements were made with special equipment. Clinical practice usually differs from those studios in thai clinical conditions rarely match those under which these drug effects were established. Laboratory grade equipment (mass or infrared spectrometry for end tidal agent detection, precision nerve stimulators, isometric force transducers with specialized armboards and recording equipment) is seldomly available or used in clinical practice. Anaesthetic depth becomes a matter of clinical judgement and simple, inexpensive equipment is used to assess neuromuscular transmission. No study to date has compared the results obtained under clinical conditions in children with those from controlled experiments. Thus, the clinician may wonder if, and how, his practice deviates from experimental observations. Therefore, we studied the onset time of twitch depression following administration of commonly used doses of succinylcholine and vecuronium during halothane, entlurane, and isoflurane anaesthesia in children. The duration of succinylcholine induced twitch depression was also studied. Clinical conditions were utilized while measurements were made with simple clinical tools. The results were compared with the times determined under controlled experimental conditions reported in the literature. MethodsThis study was approved by the Committee on Human Use of the University of Michigan. Subjects selected for this study were 2-13 years of age and of ASA physical status I or I1. They were free of known neuromuscular, cardiovascular, or renal disease and were scheduled to CAN 3 ANAESTH 1988 ! 35; 6 / t~9576-Sl)

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Isoflurane in Paediatric Anesthesia

Cited by 3 publications

References 1 publication

The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis

The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis

Observations on the Effects of Inhaled Isoflurane in Long-term Sedation of Critically Ill Children Using a Modified AnaConDa©-System

The onset of ablation of the evoked adductor pollicis muscle twitch in children: a clinical perspective

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