Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations
Leesa Joyce,
Clara Carrillo Mas,
Veronica Meedt
et al.
Abstract:Isoflurane anesthesia (IA) partially compensates NREM sleep (NREMS) and not REM sleep (REMS) requirement, eliciting post-anesthetic REMS rebound. Sleep deprivation triggers compensatory NREMS rebounds and REMS rebounds during recovery sleep as a result of the body’s homeostatic mechanisms. A combination of sleep deprivation and isoflurane anesthesia is common in clinical settings, especially prior to surgeries. This study investigates the effects of pre-anesthetic sleep deprivation on post-anesthetic sleep–wak… Show more
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