Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression

Rammes, Gerhard; Starker, Laura; Haseneder, Rainer; Berkmann, Jasmin; Plack, Alexandra; Zieglgänsberger, W.; Ohl, Frauke; Kochs, Eberhard; Blobner, Manfred

doi:10.1016/j.neuropharm.2008.11.002

Cited by 92 publications

(70 citation statements)

References 59 publications

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“…Brain slice preparations and electrophysiological experimental protocols were performed as previously described [32,33] with minor modifications. In brief, male (7-11 weeks old) C57BL/6J mice (Janvier, France) were sacrificed by cervical dislocation.…”

Section: Brain Slice Preparationmentioning

confidence: 99%

Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory

Monje¹,

Kim

Pollak³

et al. 2011

Neurosignals

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The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase abundantly expressed in the mammalian brain and highly enriched in neuronal growth cones. Inhibitory and facilitatory activities of FAK on neuronal growth have been reported and its role in neuritic outgrowth remains controversial. Unlike other tyrosine kinases, such as the neurotrophin receptors regulating neuronal growth and plasticity, the relevance of FAK for learning and memory in vivo has not been clearly defined yet. A comprehensive study aimed at determining the role of FAK in neuronal growth, neurotransmitter release and synaptic plasticity in hippocampal neurons and in hippocampus-dependent learning and memory was therefore undertaken using the mouse model. Gain- and loss-of-function experiments indicated that FAK is a critical regulator of hippocampal cell morphology. FAK mediated neurotrophin-induced neuritic outgrowth and FAK inhibition affected both miniature excitatory postsynaptic potentials and activity-dependent hippocampal long-term potentiation prompting us to explore the possible role of FAK in spatial learning and memory in vivo. Our data indicate that FAK has a growth-promoting effect, is importantly involved in the regulation of the synaptic function and mediates in vivo hippocampus-dependent spatial learning and memory.

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Section: Brain Slice Preparationmentioning

confidence: 99%

Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory

Monje¹,

Kim

Pollak³

et al. 2011

Neurosignals

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“…The importance of this may lie in the requirement for a specific balance between these subunits, with a shift in their relative expression occurring progressively throughout development. The balance between these two subunits is critical in regulating neuronal function and early brain development (Brigman et al, 2010;McKay et al, 2012;Rammes et al, 2009) as well as cell viability and degeneration (Hardingham and Bading, 2010).…”

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confidence: 99%

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

et al. 2013

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Glutamate receptors sensitive to N-methyl-D-aspartate (NMDA) are important in early brain development, influencing cell proliferation and migration, neuritogenesis, axon guidance and synapse formation. The kynurenine pathway of tryptophan metabolism includes an agonist (quinolinic acid) and an antagonist (kynurenic acid) at these receptors.Rats were treated in late gestation with 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]-benzene-sulphonamide (Ro61-8048), an inhibitor of kynurenine-3-monoxygenase which diverts kynurenine metabolism to kynurenic acid. Within 5h of drug administration there was a significant decrease in GluN2A expression and increased GluN2B in the embryo brains, with changes in sonic hedgehog at 24h. When injected dams were allowed to litter normally, the brains of offspring were removed at postnatal day 21 (P21). Recordings of hippocampal field excitatory synaptic potentials (fEPSPs) showed that prenatal exposure to Ro61-8048 increased neuronal excitability and paired-pulse facilitation. Long-term potentiation was also increased, with no change in long-term depression. At this time, levels of GluN2A, GluN2B and postsynaptic density protein PSD-95 were all increased.Among several neurodevelopmental proteins, the expression of sonic hedgehog was increased, but DISC1 and dependence receptors were unaffected, while raised levels of doublecortin and Proliferating Cell Nuclear Antigen (PCNA) suggested increased neurogenesis. The results reveal that inhibiting the kynurenine pathway in utero leads to molecular and functional synaptic changes in the embryos and offspring, indicating that the pathway is active during gestation and plays a significant role in the normal early development of the embryonic and neonatal nervous system. 3

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“…Studies have shown that dependence occurred when the cerebral ventricle of rats was bathed with butorphanol; the mRNA levels of the NR1 subunit decreased significantly in the cerebral cortex, pituitary, and hippocampal CA1 zone; the mRNA levels of the NR2A subunit increased significantly in the cerebral cortex and the hippocampal dentate gyrus zone; and the mRNA contents of the NR2B subunit decreased in the cerebral cortex, caudoputamen, pituitary, and the hippocampal CA3 zone (Zhu et al, 1999;Oh et al, 2000). The n-methyld-aspartate (NMDA) receptor is closely associated with cognitive function (Rammes et al, 2009;Mawhinney et al, 2012). Future studies should be conducted to determine whether the effects of dezocine and butorphanol on cognitive function are related to the NMDA receptor.…”

Section: Discussionmentioning

confidence: 99%

Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients

et al. 2015

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ABSTRACT. The aim of this study was to observe the analgesic effects of the combination of dezocine and butorphanol on postoperative cognitive function in elderly patients. Forty elderly patients undergoing upper abdominal surgeries or thoracotomies with general anesthesia were randomly divided into the dezocine and butorphanol group or the butorphanol group (20 patients per group). A visual analog scale was used to evaluate analgesia and the degree of malignant vomiting. The Ramsay scoring method was used to evaluate sedation. The Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. Forty-eight hours after the operation, the pain score of the dezocine and butorphanol group (means ± SD, 1.75 ± 0.44) was lower than that of the butorphanol group (2.25 ± 0.79; P < 0.05), and the nausea and vomiting score of the dezocine and butorphanol group (0) was lower than that of the butorphanol group (0.70 ± 1.30; P < 0.05). Six hours after the operation, the sedative score of the butorphanol group (3.75 ± 0.79) was higher than that of the dezocine and butorphanol group (2.15 ± 0.75; P < 0.05). Compared to 1 day before the operation, the MMSE B.X. Ren et al. 5572©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 5571-5576 (2015) scores of both groups decreased 6 h after the operation, and the MMSE score of the butorphanol group (15.00 ± 2.00) was lower than that of the dezocine and butorphanol group (20.95 ± 1.54; P < 0.05). Dezocine and butorphanol analgesia had transient effects on postoperative cognitive function in elderly patients, and the effect of the combination was superior than butorphanol only.

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Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression

Cited by 92 publications

References 59 publications

Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory

Focal Adhesion Kinase Regulates Neuronal Growth, Synaptic Plasticity and Hippocampus-Dependent Spatial Learning and Memory

Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus

Effects of intravenous analgesia with combined dezocine and butorphanol on postoperative cognitive function in elderly patients

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