“…activate K ATP channels not only in pancreatic β cells, but also in cardiac myocytes (Fujimoto et al, 2002) and vascular smooth muscle cells (Tanaka et al, 2007). It has been reported that volatile anesthetics have cardioprotective and vasodilative effects mediated by activation of cardiac (Tanaka et al, 2003(Tanaka et al, , 2004 and vascular K ATP channels (Tanaka et al, 2007), respectively. The present results indicate that isoflurane impairs glucose tolerance and insulin secretion via activation of pancreatic K ATP channels.…”