Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode

Abstract

Succinate dehydrogenase inhibitors (SDHIs) have played a crucial role in disease control to protect cereals as well as fruit and vegetables for more than a decade. Isoflucypram, the first representative of a newly installed subclass of SDHIs inside the Fungicide Resistance Action Committee (FRAC) family of complex II inhibitors, offers unparalleled long‐lasting efficacy against major foliar diseases in cereals. Herein we report the chemical optimization from early discovery towards isoflucypram and the first hypothesis of its altered binding mode in the ubiquinone binding site of succinate dehydrogenase. © 2020 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Synthesis, Bioactivity Evaluation,3D‐QSAR, and Molecular Docking of Novel Pyrazole‐4‐carbohydrazides as Potential Fungicides Targeting Succinate Dehydrogenase

“…[ 9‐10 ] With the development of furametpyr in 1997, the mechanism of action of SDHIs has attracted widespread attention from researchers, [ 11 ] and many new SDHI fungicides have been developed, such as fluxapyroxad, [ 12 ] penflufen, [ 13 ] and isoflucypram (Figure 1). [ 13‐14 ]…”

A Journal of the Plague Year

“…A related paper reviews the parameters that are drivers in the dynamics of barley yellow dwarf virus epidemiology that are needed in decision support models for managing this important pest 24 . Desbordes et al 25 . review the discovery and mode of action of the fungicide isoflucypram.…”

“…23 A related paper reviews the parameters that are drivers in the dynamics of barley yellow dwarf virus epidemiology that are needed in decision support models for managing this important pest. 24 Desbordes et al 25 review the discovery and mode of action of the fungicide isoflucypram. The role of effector recognition in plant/pathogen interactions and how this can be used in selecting crop resistance genes is discussed in a perspective.…”

Erratum: Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode

“…Three structures were mistakenly omitted during production of the article by Desbordes et al 1 They should have appeared after Tables 1, 2 and 3 respectively and are provided here:…”