Isoflavones versus hormone therapy for reduction of vertebral fracture risk

Bolaños, Rafael; Francia, José

doi:10.1097/gme.0b013e3181df48f0

Cited by 22 publications

(8 citation statements)

References 19 publications

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“…Epidemiological studies suggest high intakes of isoflavones to be associated with fewer and less intense menopause symptoms, and a reduced incidence of hormone-dependent and aging-associated diseases such as osteoporosis, cardiovascular diseases and cancer [1]. Although there is a growing body of scientific evidence showing beneficial effects in counteracting symptoms such as hot flushes and vasomotor reactions in menopausal women [2], the European Food Safety Authority (EFSA) has recently refuted health claims about the role of isoflavones in body functions [3]. This may be so because the functionality of isoflavones depends on their bioavailability and their conversion into (more) active metabolites within the intestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

et al. 2017

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BackgroundIsoflavones are polyphenols with estrogenic activity found mainly in soy and soy-derived products that need to be metabolised in the intestine by the gut bacteria to be fully active. There is little knowledge about isoflavone bioconversion and equol production in the human intestine. In this work, we developed an in vitro anaerobic culture model based on faecal slurries to assess the impact of isoflavone supplementation on the overall intestinal bacterial composition changes and associated metabolic transformations.ResultsIn the faecal anaerobic batch cultures of this study bioconversion of isoflavones into equol was possible, suggesting the presence of viable equol-producing bacterial taxa within the faeces of menopausal women with an equol producer phenotype. The application of high-throughput DNA sequencing of 16S rRNA gene amplicons revealed the composition of the faecal cultures to be modified by the addition of isoflavones, with enrichment of some bacterial gut members associated with the metabolism of phenolics and/or equol production, such as Collinsella, Faecalibacterium and members of the Clostridium clusters IV and XIVa. In addition, the concentration of short-chain fatty acids (SCFAs) detected in the isoflavone-containing faecal cultures was higher in those inoculated with faecal slurries from equol-producing women.ConclusionsThis study constitutes the first step in the development of a faecal culturing system with isoflavones that would further allow the selection and isolation of intestinal bacterial types able to metabolize these compounds and produce equol in vitro. Although limited by the low number of faecal cultures analysed and the inter-individual bacterial diversity, the in vitro results obtained in this work tend to indicate that soy isoflavones might provide an alternative energy source for the increase of equol-producing taxa and enhancement of SCFAs production. SCFAs and equol are both considered pivotal bacterial metabolites in the triggering of intestinal health-related beneficial effects.Electronic supplementary materialThe online version of this article (doi:10.1186/s12866-017-1001-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

et al. 2017

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“…No association was found between isoflavones consumption and risk of osteoporotic vertebral fracture in postmenopausal women . However, isoflavone treatments exert a moderately beneficial effect against estrogen‐deficient bone loss in women .…”

Section: Resultsmentioning

confidence: 97%

“…No association was found between isoflavones consumption and risk of osteoporotic vertebral fracture in postmenopausal women. [47] However, isoflavone treatments exert a moderately beneficial effect against estrogen-deficient bone loss in women. [48] It also moderately decreased the bone resorption marker deoxypyridinoline, but did not affect bone formation markers bone alkaline phosphatase and osteocalcin in menopausal women.…”

Section: Musculoskeletal Outcomesmentioning

confidence: 99%

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Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans

Zhuang

et al. 2019

Molecular Nutrition Food Res

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Scope To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. Methods and results This is an umbrella review of meta‐analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta‐analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02–1.36) for high intake of miso soup (1–5 cups per day) in male. Conclusion Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.

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“…A new meta-analysis [1] of 19 intervention reports concluded that there was a significant tendency in favor of finding that soy eased hot flushes, but also that there was great heterogeneity in the results of the published reports. The most recent meta-analysis on osteoporosis, which included data from 1,240 menopausal women, revealed that daily ingestion of soy isoflavone extract supplements for 6 to 12 months increased spine bone mineral density by 2.38%, but that no significant effects on femoral neck, hip total and trochanter bone mineral density were found [2].…”

Section: Isoflavones In Epidemiological and Clinical Studiesmentioning

confidence: 99%

Does consuming isoflavones reduce or increase breast cancer risk?

Bondesson

Gustafsson

2010

Genome Medicine

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Epidemiological studies suggest that consumption of phytoestrogens, in particular isoflavones, correlates with a lower incidence of breast cancer. However, data from human intervention studies have been less clear. Several meta-analyses have reported beneficial but relatively weak effects of isoflavone consumption on reduction of hot flushes and osteoporosis and improvement of cholesterol levels. However, the effects of isoflavones on early breast cancer markers differ between pre- and post-menopausal women. Conclusions on whether exposure of animals (mice and rats) to isoflavones protects against or promotes breast cancer development and growth vary between different studies. These results, taken together with the heterogeneous outcomes of human interventions, have led to a controversy surrounding the intake of isoflavone to reduce breast cancer risk. Here, we describe the results of recent human and animal intervention studies and discuss factors that might explain the variation in results. We also describe possible molecular mechanisms of action of isoflavones; distinguishing which mechanism(s) are involved is needed if we are to solve the controversy surrounding the actions of these compounds.

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Isoflavones versus hormone therapy for reduction of vertebral fracture risk

Abstract: According to this indirect comparison, there is no statistically significant difference between HT or isoflavones in the reduction of vertebral fracture risk due to osteoporosis, and both interventions seem to be similar for this outcome.

Cited by 22 publications

References 19 publications

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans

Does consuming isoflavones reduce or increase breast cancer risk?

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