Isoflavones in gynecology

Carbonel, Adriana Aparecida Ferraz; Simões, Ricardo Santos; Girão, João Henrique Castello; Sasso, Gisela Rodrigues da Silva; Bertoncini, Clélia Rejane Antônio; Sorpreso, Isabel Cristina Espósito; Soares, José Maria; Simões, Manuel J.; Baracat, Edmund Chada

doi:10.1590/1806-9282.64.06.560

Cited by 13 publications

(14 citation statements)

References 29 publications

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“…Isoflavones also exert a dose-dependent action during in vitro and in vivo conditions. In normal doses, they act as estrogen modulators (Carbonel et al, 2018) whereas at high doses it reduces cell proliferation (Talsness et al, 2015). Furthermore, in low doses, they act as stimulator and were Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review able to modify genes responsible for cell cycle control (Touny and Benerjee, 2006), cell survival (Moiseeva et al, 2007) and apoptosis (Touny and Benerjee, 2006).…”

Section: Isoflavonoidsmentioning

confidence: 99%

Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review

Kumar¹,

Manasa²,

Ramesh³

et al. 2021

IJAR

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Phytochemicals present in the plants are divided into primary (Alcohol Amino acids, nucleotides. etc) and secondary metabolites (Alkaloids, Saponins etc.). Carotenoids (reduces reactive oxygen species formation, decreases apoptotic cells, restoration of actin capping expression proteins etc.), Phenolics (inhibits extracellular signal-regulated kinase signalling pathway), Isoflavones (inhibits tyrosine kinase pathway) and alkaloids (downregulation of vascular endothelial growth factor, tumor necrosis factor-alpha and hypoxia-inducible factor 1-alpha messengers) are the major phytochemicals, having the potential effects towards ovarian function. Likewise, bioactive compounds are the chemicals that can interact with certain components of live tissue to exert their various effects (antioxidant, antineoplastic, receptor inhibition, gene expression etc.) respective to female fertility. Similarly, bioactive compounds: Kaempferol [phosphatidylinositol -3- kinase (PI3K)/protein kinase B (Akt) pathway], Quercetin (controlling the release of 17β-estradiol etc.), Myricetin (PI3K/Akt and MAPK signalling pathway), Galngin (inhibition of angiogenesis via decreasing the VEGF and p-Akt) and Resveratrol (regulation of Foxo3a and SIRT1 genes etc.) shows its effects by targeting different molecules and/or pathways at the ovarian microenvironment. However, Genistein (binding to estrogen receptors: ESRα and ESRβ etc.) and Diadzein (disrupting the endocrines etc.) emphatically interfere with the ovarian functions. Besides this, molecular effects exerted by these phyto-bioactive compounds on the in vivo and/or in vitro ovarian culture systems entirely depend on their dosage: Kaempferol @10 μM increased the primordial follicle activation, Quercetin @4 µM improved the quality of oocytes whereas @8 µM reduced the quality), Resveratrol @ 2 µM increased the blastocyst formation, Myricetin @ 100 mg/kg/day feeding in rats induced estrogenic activity, Genistein, feeding in female mice @ 500 and 1000ppm increased the gestation time and Diazdein causes the inhibition of 3-hydroxysteroid dehydrogenase at 40 µM doses. The assessment was done via the systemic collection of literature from sources such as newspapers, conference papers, journals, theory and dissertation articles, electronic databases, manuals, encyclopedia and annual reviews, as well as e-books and reporting. As a result, the preceding discussion focuses on the key phyto-bioactive compounds and their molecular targets in female fertility. This will aid in the successful and secure application of plant bioactive compounds in the field of female reproductive health.

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Section: Isoflavonoidsmentioning

confidence: 99%

Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review

Kumar¹,

Manasa²,

Ramesh³

et al. 2021

IJAR

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“…Isoflavones are classified as phytoestrogens with structural similarity to 17 β-estradiol. Isoflavones exhibit weak estrogenic activity as they interact with estrogen receptor (ER) ER-β and to a lesser extent ER-α, so they were considered as selective ER modulators, and potential alternatives to HRT 4 . There are 12 different isoflavones detected in soybean: three aglycones; genistein, daidzein and glycitein, their respective β-glycosides; genistin, daidzin and glycitin along with the 3 β-glucosides each esterified with either malonic or acetic acid 5 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women

Salam¹,

Raslan²,

Mohamed³

et al. 2021

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Introduction: Great concern has been raised recently concerning the therapeutic impact of soybean. The present study aims to investigate the effects of soybean on bone health and metabolic parameters in postmenopausal women. Methods: In this clinical study, 72 healthy postmenopausal women aged between 45-65 years were given soybean bioactive fraction 2 capsules (500mg each) daily for 24 weeks. Each capsule contained 31.25 mg proteins, 3.2 mg carbohydrates and 4.84 mg isoflavones. Blood pressure, bone mineral density, plasma osteocalcin (OCN), telopeptides of collagen type I (CTX), fasting insulin and blood glucose, lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and TSH were assessed prior and after the period of the study. Insulin resistance was calculated by homeostatic model assessment-IR formula (HOMA-IR). Results: Soy ingestion resulted in a significant increase in T score of the hip and OCN; recording -1.97±0.13/-1.76±0.12 and 22.44±0.60ng/ml/30.93±0.57ng/ml before/after treatment, respectively. A marked decrease was also detected in CTX from 2.22±0.10ng/ml to 1.48±0.08ng/ml. With regard to metabolic parameters, there was a significant decrease in fasting insulin (5.40±0.62uU/ml vs 4.15±0.45uU/ ml), however, fasting glucose and HOMA-IR showed no significant alterations. Lipid profile displayed remarkable decline in total cholesterol (188.86±7.23mg/dl vs 159.60±4.72mg/dl, triglycerides (97.09±5.23mg/dl vs 83.56±4.27mg/dl), LDL-c (75.60±3.06mg/dl vs 63.95±1.86mg/ dl) accompanied with a significant elevation in HDL-c (53.09±0.88 vs 65.81mg/dl±0.80mg/ dl). A significant decrease in both TSH (1.97±0.13 uIU/ml vs 1.40±0.08 uIU/ml) and serum creatinine (0.82±0.02mg/dl vs0.77±0.02mg/dl) was also noticed. Conclusion: Consumption of soy improves bone health, reduces cardiovascular risk with no adverse effects on kidney, liver or thyroid functions.

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“…Então, a partir de 2001, empregou-se uma nova nomenclatura que abrangesse e separasse os estágios da vida da mulher, sobretudo em relação às dosagens hormonais de cada fase 9 . Os períodos reprodutivos e não reprodutivos da mulher foram definidos pela North American Menopause Society em cinco períodos reprodutivos e dois não reprodutivos [9][10][11] .…”

Section: Introductionunclassified

“…A menopausa é definida pela interrupção permanente da menstruação, após 12 meses de amenorreia fisiológica. Essa alteração acontece devido à insuficiência da atividade folicular ovariana, que geralmente inicia aos 40 anos 11,12 . Em países desenvolvidos a menopausa pode ocorrer ao redor dos 52 anos, no Brasil entre 48 e 50 anos [13][14][15] , sendo considerada sua ocorrência normal a partir dos 40 até os 54 anos.…”

Section: Introductionunclassified

“…O período +1b, tem durabilidade de um ano, cursando com rápidas modificações nos níveis de FSH e estradiol e maior probabilidade de ocorrência dos sintomas menopausais, em especial os vasomotores. O estágio +1c retrata a estabilização de níveis elevados de FSH e diminutos de estradiol, com duração de 5 a 8 anos até a morte9,11 .A pós-menopausa tardia (estagio +2) apresenta limitações nas funções endócrinas e reprodutivas. O envelhecimento somático necessita de relevante atenção pela presença de secura vaginal e atrofia urogenital.…”

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Modulação autonômica cardíaca em mulheres na pós-menopausa com síndrome do olho seco

Júnior¹,

de²

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Isoflavones in gynecology

Cited by 13 publications

References 29 publications

Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review

Molecular Targets of Phyto-bioactive Compounds in Female Reproductive System of Mammals: A Review

Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women

Modulação autonômica cardíaca em mulheres na pós-menopausa com síndrome do olho seco

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