Isoflavones decrease insomnia in postmenopause

Abstract

In postmenopausal women with insomnia, isoflavone treatment was effective in reducing insomnia symptoms, which was confirmed by increased sleep efficiency as observed by polysomnographic analysis.

Sleep disturbances in menopausal women: Aetiology and practical aspects

“…Sleep efficiency was improved on PSG in the treated group: 78-84% versus 78-81% in the placebo group. Sleep complaints decreased from 90% to 37% in treated group versus 95% to 63% in the placebo group [12]. These findings have to be confirmed in further studies.…”

Cognitive Behavioral Therapy in the Treatment of Insomnia

“…Ramelteon did not reduce sleep onset latency compared with placebo (low-strength evidence). The only study longer than 3 months 127 reported an improvement in sleep onset latency of -6.8 minutes (95% CI, -13.5 to -0.1). Low-strength evidence found that ramelteon did not significantly improve total sleep time or wake time after sleep onset compared to placebo.…”

“…[126][127][128][129] Two of the trials, NCT00237497 and NCT00671567, only had results published in a systematic review. The trials randomized 3124 participants; mean age was 45; 63 percent were female.…”

“…Two trials were conducted in the United States, 126,129 one in Japan, 128 and two were multinational. 126,127 Dosing ranged from 4 to 16 mg. All trials were short term (4 to 5 weeks) with the exception of Mayer et al, which lasted 6 months. 127 All trials reported industry sponsorship and had moderate risk of bias.…”

Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen

“…One study reported on the number of subjects experiencing an increased or decreased severity, or an increased frequency, of hot flushes in the intervention and control group without presenting a statistical analysis (Pop et al, 2008). In another study (Hachul et al, 2011), differences in the baseline frequency of hot flushes between groups were not taken into account in the analysis, and in EFSA Journal 2012;10(8):2847…”