Isoflavones alter male and female fertility in different development windows

Sleiman, Hanan Khaled; Oliveira, Jeane Maria de; Freitas, Guilherme Barroso Langoni de

doi:10.1016/j.biopha.2021.111448

Cited by 27 publications

(30 citation statements)

References 78 publications

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“…[20,21] As for the weights of the uterus and ovary, our study corroborated that the uterine weight in the DAI group was significantly higher than the other groups. [22] These findings buttress the notion that soy can play a role in early pubertal development. [6,23,24] The gut microbiota plays a vital role in metabolic and hormonal homeostasis.…”

Section: Discussionmentioning

confidence: 71%

“…A maximum of three mice from the same litter were used in any given group. Mice received DAI at the dose of 100 mg kg ‐1 d ‐1[ 11 ] and/or probiotic at the dose of 100 mg kg ‐1 d ‐1 ( Bifidobacterium longum 0.4 × 10 8 CFU kg ‐1 ) gavage every morning (10:00 am) from P21 to P27. The Con group was given an identical volume of normal saline by gavage daily.…”

Section: Methodsmentioning

confidence: 99%

“…These inconsistencies may relate to the timing of exposure. [11] Soy could be a risk factor because it contains isoflavones, secondary metabolites belonging to phytoestrogens, which have a similar molecular structure to 17𝛽estradiol. [12] Therefore, soy isoflavones (SI) bind to estrogen receptors, triggering agonist, can promote CPP.…”

Section: Introductionmentioning

confidence: 99%

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Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Yuan

Shangguan

Zhang

et al. 2023

Molecular Nutrition Food Res

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Background The relationship between soy isoflavones (SI)‐induced gut dysbiosis and puberty onset has not been explored, and the protective effect of probiotic is still controversial. This study investigates the action of daidzein (the main components of SI) and probiotic on the age of puberty onset in female mice. Methods and results Changes in the gut microbiota and production of short chain fatty acids (SCFAs) metabolism are highlighted to analyze a possible causative relationship to puberty onset in female c57/bl mice. The results demonstrate that daidzein promotes earlier onset of puberty, and can significantly alter the composition of the fecal bacterial community. Furthermore, daidzein alters the gut microbiota such that levels of butyrate, isovalerate, and hexanoate are reduced. Moreover, a probiotic treatment normalizes the timing of puberty onset, likely due to alteration in the gut microbiota to enhance SCFAs production. Conclusion These findings provide evidence that 95% daidzein has the potential to advance the timing of puberty onset in female mice, and the gut microbiome can be a therapeutic target to regulate the timing of puberty onset.

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Section: Discussionmentioning

confidence: 71%

Section: Methodsmentioning

confidence: 99%

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Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Yuan

Shangguan

Zhang

et al. 2023

Molecular Nutrition Food Res

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“…Some plant extracts act as EEDs, as they are among a group of secondary metabolites with chemical structures similar to those of endogenous hormones. Isoflavones are phytoestrogens that are mainly produced in soybeans and can promote advancement of the vaginal opening in female rats after exogenous supplementation ( 61 ). Galangin is a naturally occurring flavonoid that inhibits the effects of flavonoids on human cytochrome P450 ( 62 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Feng

Qin

et al. 2022

Front. Endocrinol.

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Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased. Environmental endocrine disruptors (EEDs) are chemicals that may interfere with the endocrine system, resulting in adverse developmental, immunological, neurological, and reproductive effects in humans. Thus, the effects of EEDs on fertility and reproduction are growing concerns in modern societies. In this study, we aimed to determine the influence of genetic and environmental factors on AAM. We used data from an AAM genome-wide association study of 329,345 women to conduct a transcriptome-wide association study (TWAS) with FUSION software. As references, we determined the gene-expression levels in the hypothalamus, pituitary gland, ovaries, uterus, and whole blood. We performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses using the significantly dysregulated genes identified by the TWAS. Using the STRING database, we also generated a protein–protein-interaction network to analyze common AAM-specific genes identified by the TWAS with different tissues. We performed chemical-related gene set enrichment analysis (CGSEA) and identified significant TWAS genes to uncover relationships between different chemicals and AAM. The TWAS identified 9,848 genes; among these, 1580 genes were significant (P < 0.05), and 11 genes were significant among the hypothalamus, pituitary, ovary, uterus, and whole blood. CGSEA identified 1,634 chemicals, including 120 chemicals significantly correlated with AAM. In summary, we performed a TWAS (for genetic factors) and CGSEA (for environmental factors) focusing on AAM and identified several AAM-associated genes and EEDs. The results of this study expand our understanding of genetic and environmental factors related to the onset of female puberty.

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“…Many studies have been performed that demonstrate the positive effects of edible phytoestrogens on climacteric symptoms, such as [ 9 ], for instance, and also on the prevention of bone loss [ 10 ]. However, recent studies have shown that phytoestrogen exposure prior to menopause can lead to adverse effects on reproductive physiology [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Phytoestrogens and Health Effects

Canivenc-Lavier

Bennetau-Pelissero

2023

Nutrients

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Phytoestrogens are literally estrogenic substances of plant origin. Although these substances are useful for plants in many aspects, their estrogenic properties are essentially relevant to their predators. As such, phytoestrogens can be considered to be substances potentially dedicated to plant–predator interaction. Therefore, it is not surprising to note that the word phytoestrogen comes from the early discovery of estrogenic effects in grazing animals and humans. Here, several compounds whose activities have been discovered at nutritional concentrations in animals and humans are examined. The substances analyzed belong to several chemical families, i.e., the flavanones, the coumestans, the resorcylic acid lactones, the isoflavones, and the enterolignans. Following their definition and the evocation of their role in plants, their metabolic transformations and bioavailabilities are discussed. A point is then made regarding their health effects, which can either be beneficial or adverse depending on the subject studied, the sex, the age, and the physiological status. Toxicological information is given based on official data. The effects are first presented in humans. Animal models are evoked when no data are available in humans. The effects are presented with a constant reference to doses and plausible exposure.

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Isoflavones alter male and female fertility in different development windows

Cited by 27 publications

References 78 publications

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Intervention Effect of Probiotics on the Early Onset of Puberty Induced by Daidzein in Female Mice

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Phytoestrogens and Health Effects

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