Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Inpan, Ratchanon; Na Takuathung, Mingkwan; Sakuludomkan, Wannachai; Dukaew, Nahathai; Teekachunhatean, Supanimit; Koonrungsesomboon, Nut

doi:10.1007/s00198-023-06944-y

Cited by 2 publications

(1 citation statement)

References 103 publications

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“…Based on 63 RCTs (n = 4754) and a placebo group (n = 4272), isoflavone interventions significantly improved lumbar spine BMD (MD = 0.0175 g/cm 2 ; 95% CI, 0.0088 to 0.0263, p < 0.0001) and femoral neck (MD = 0.0172 g/cm 2 ; 95% CI, 0.0046 to 0.0298, p = 0.0073) in postmenopausal women. A subgroup analysis revealed that an isoflavone intervention improved BMD when the therapy lasted for at least 12 months and contained genistein at a dosage of at least 50 mg per day [33].…”

Section: Impact Of Isoflavonoids On Bone Mineral Densitymentioning

confidence: 99%

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Miedziaszczyk,

Maciejewski,

Idasiak-Piechocka

et al. 2023

Nutrients

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Phytoestrogens are non-steroidal plant compounds, which bind to α and β estrogen receptors, thereby causing specific effects. The best-known group of phytoestrogens are flavonoids, including isoflavonoids—genistein and daidzein. They play a role in the metabolism of bone tissue, improving its density and preventing bone loss, which contributes to reducing the risk of fractures. Vitamin D is found in the form of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) and is traditionally recognized as a regulator of bone metabolism. The aim of this review was to evaluate the synergistic effect of isoflavonoids and vitamin D on bone mineral density (BMD). The MEDLINE (PubMed), Scopus and Cochrane databases were searched independently by two authors. The search strategy included controlled vocabulary and keywords. Reference publications did not provide consistent data regarding the synergistic effect of isoflavonoids on BMD. Some studies demonstrated a positive synergistic effect of these compounds, whereas in others, the authors did not observe any significant differences. Therefore, further research on the synergism of isoflavonoids and vitamin D may contribute to a significant progress in the prevention and treatment of osteoporosis.

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Section: Impact Of Isoflavonoids On Bone Mineral Densitymentioning

confidence: 99%

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Miedziaszczyk,

Maciejewski,

Idasiak-Piechocka

et al. 2023

Nutrients

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From Plant to Patient: The Metabolic Benefits of Phytoestrogens

Kumar Verma,

Kumar Singh,

Tripathi

2024

Herbs and Spices - New Perspectives in Human Health and Food Industry [Working Title]

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In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, a diverse group of naturally occurring compounds found in plants. These compounds, with structural similarities to estrogen, are found in foods such as soybeans, flaxseeds and sesame seeds, and are studied for their roles in modulating hormonal activity and antioxidant properties. Their estrogen-like functions make them particularly interesting in managing conditions exacerbated by hormonal imbalances, such as type 2 diabetes, obesity, cardiovascular diseases, and osteoporosis. Phytoestrogens enhance insulin sensitivity and glucose metabolism, while their anti-oxidant properties neutralize free radicals and inhibit lipid peroxidation. They also influence fat metabolism and reduce adipogenesis, addressing oxidative stress and inflammation. Their estrogenic effects improve bone mineral density and reduce fracture risks, particularly in postmenopausal women, highlighting their broad potential in metabolic disease management. This growing body of research suggests that phytoestrogens, due to their unique properties and diverse mechanisms of action, could be a valuable addition to dietary and therapeutic strategies in the prevention and management of various metabolic diseases. This chapter delves into the multifaceted roles of phytoestrogens in metabolic disorders, with a special focus on their antioxidant properties.

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Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

Cited by 2 publications

References 103 publications

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density—A Systematic and Critical Review

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

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