Isoechinatine, a Pyrrolizidine Alkaloid from Cynoglossum furcatum

Ravikumar, R.; Lakshmanan, A. J.

doi:10.1002/chin.200422212

Cited by 3 publications

(3 citation statements)

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“…[ [70][71][72] C. furcatum (C. zeylanicum) Echinatine, isoechinatine, neocoromandaline, cynaustraline, lactodine, viridinatine [73][74][75][76] C. germanicum Echinatine, viridiflorine.…”

Section: Speciesmentioning

confidence: 99%

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Diversity of Pyrrolizidine Alkaloids in the Boraginaceae Structures, Distribution, and Biological Properties

2014

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Among the diversity of secondary metabolites which are produced by plants as means of defence against herbivores and microbes, pyrrolizidine alkaloids (PAs) are common in Boraginaceae, Asteraceae and some other plant families. Pyrrolizidine alkaloids are infamous as toxic compounds which can alkylate DNA und thus cause mutations and even cancer in herbivores and humans. Almost all genera of the family Boraginaceae synthesize and store this type of alkaloids. This review reports the available information on the present status (literature up to early 2014) of the pyrrolizidine alkaloids in the Boraginaceae and summarizes the topics structure, distribution, chemistry, chemotaxonomic significance, and biological properties.

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“…[ [70][71][72] C. furcatum (C. zeylanicum) Echinatine, isoechinatine, neocoromandaline, cynaustraline, lactodine, viridinatine [73][74][75][76] C. germanicum Echinatine, viridiflorine.…”

Section: Speciesmentioning

confidence: 99%

“…Plants belongs to this genus contain alkaloids mainly derived from heliotridine type, in addition to (+)-and (−)-supinidine and trachelanthamidine bases [60,[67][68][69][70][71][72][73][74][75][76][77][78][80][81][82][83][84][85][86]239]. …”

Section: Genus Cynoglossummentioning

confidence: 99%

Diversity of Pyrrolizidine Alkaloids in the Boraginaceae Structures, Distribution, and Biological Properties

2014

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“…Three new alkaloids were isolated from the roots of Cynoglossum furcatum and their structures assigned on the basis of spectroscopic evidence as isoechinatine 25, 23 lactodine 26, a lactate ester of heliotridine, and viridinatine 27, a derivative of echinatine. 24 Work to develop solid-phase extraction methods and HPLC-ESI/MS proling of pyrrolizidine alkaloids, using Echium plantagineum as a case study, identied higher ratios of pyrrolizidine N-oxides to free-bases than had previously been reported for this species.…”

Section: Isolationmentioning

confidence: 99%