Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics
Bhavna Kaveti,
Manuel A. Rentería‐Gómez,
Alejandro Corona‐Díaz
et al.
Abstract:Multicomponent diversity‐oriented synthesis (DOS) of conformationally anchored structural peptidomimetics like 2,5‐diketopiperazines (2,5‐DKP) containing heterocyclic bioisosteres of the amide bond, such as 1,2,3‐triazoles and 1,5‐disubstituted tetrazoles (1,5‐DS‐T) is described. Structural peptidomimetics are synthesized from similar available starting materials, via a strategy based on isocyanide‐based multicomponent reactions (IMCRs): Ugi‐4CR and Ugi‐Azide (UA), followed by a one‐pot process: SN2/intramolec… Show more
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