Isocoumarins and benzofurans from the mangrove endophytic fungus Talaromyces amestolkiae possess α-glucosidase inhibitory and antibacterial activities

Chen, Senhua; Liu, Yayue; Liu, Zhaoming; Cai, Runlin; Lü, Yongjun; Huang, Xishan; She, Zhigang

doi:10.1039/c6ra02566h

Cited by 96 publications

(71 citation statements)

References 34 publications

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“…It was obtained using the standard protocol for the isolation of endophytic microbes [8]. This isolate was identified by Yayue Liu and assigned the accession number ZJ-SY 2 .…”

Section: Methodsmentioning

confidence: 99%

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Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

et al. 2016

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Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY 2 isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC 50 values ranging from 5.9 to 9.3 µg/mL.

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“…It was obtained using the standard protocol for the isolation of endophytic microbes [8]. This isolate was identified by Yayue Liu and assigned the accession number ZJ-SY 2 .…”

Section: Methodsmentioning

confidence: 99%

“…In the past decades, our research group had been focusing on the exploration of new bioactive metabolites from mangrove endophytic fungi collected from the South China Sea [6,7,8,9,10,11,12,13]. The EtOAc extract of the fermentation of a mangrove endophytic fungus, Penicillium sp.…”

Section: Introductionmentioning

confidence: 99%

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

et al. 2016

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“…The assays for antibacterial [23] and α-glucosidase inhibitory [23] were carried out as described previously.…”

Section: Methodsmentioning

confidence: 99%

New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

Xiao¹,

Chen²,

Cai³

et al. 2016

Beilstein J. Org. Chem.

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SummaryThe chemical investigation of the mangrove endophytic fungus Aspergillus sp. 085242 afforded eight isocoumarin derivatives 1–8 and one isoquinoline 9. Asperisocoumarins A and B (1 and 2) were new furoisocoumarins, and asperisocoumarins E and F (5 and 6) were new isocoumarins. Their structures were established by analysis of their spectroscopic data and the absolute configuration of compound 2 was unambiguously determined by X-ray structure analysis and ECD calculation. Moreover, the absolute configurations of compounds 3–5 were assigned by comparison of their ECD spectra with isocoumarins described in the literature. Asperisocoumarins C and D (3 and 4) were fully characterized spectroscopically and isolated from a natural source for the first time. Asperisocoumarins A–D (1–4) related to the class of furo[3,2-h]isocoumarins are rarely occurring in natural sources. Compounds 2, 5, and 6 showed moderate α-glucosidase inhibitory activity with IC50 of 87.8, 52.3, and 95.6 μM, respectively. In addition, compounds 1 and 3 exhibited weak radical scavenging activity with EC50 values of 125 and 138 μM, respectively.

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“…50 µg/mL)[61]. Chen et al reported that the isocoumarins metabolites were separated from Talaromyces amestolkiae, did not exhibit any antibacterial activity against Staphylococcus epidermidis, S. aureus, Klebsiella pneumoniae, E. coli, and B. subtilis[62]. were biosynthesized by Aspergillus banksianus, were tested for in vitro antimicrobial activities against E. coli (ATCC 25922), B. subtilis (ATCC 6633), Saccharomyces cerevisiae (ATCC 9763), and C. albicans (ATCC 10231).…”

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Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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Isocoumarins and benzofurans from the mangrove endophytic fungus Talaromyces amestolkiae possess α-glucosidase inhibitory and antibacterial activities

Abstract: Six new isocoumarins, compounds1–4and14–15, two new benzofurans,16–17, along with nine known isocoumarin analogues,5–13were obtained from the mangrove endophytic fungusTalaromyces amestolkiaeYX1.

Cited by 96 publications

References 34 publications

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

New furoisocoumarins and isocoumarins from the mangrove endophytic fungus Aspergillus sp. 085242

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

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