Isochromosome 17 in a Patient with a Myeloproliferative Disorder Terminating in Eosinophilic Leukemia

Abstract

A patient is described, who for more than two years had a myeloproliferative disorder which terminated in eosinophilic leukemia. Chromosome analysis revealed an isochromosome 17 in all metaphases of bone marrow cells. This abnormality has now been found in two out of six patients with eosinophilic leukemia investigated by banding techniques, and may therefore have etiologic importance. Chromosome analysis in the hypereosinophilic syndrome has practical value for differentiating malignant and non‐malignant disease.

Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild‐typeTP53

“…Isochromosome 17q as a sole cytogenetic abnormality in myeloid neoplasms, other than blast phase of CML, has been described in single case reports2‐14 or small case series 1, 15‐22. In aggregate, these studies have described the clinical and morphologic features of myeloid neoplasms with isolated isochromosome 17q.…”